Drug by Pharmacokinetics

Question 1

Penicillin V

Answer 1

po

renal excretion

Question 2

Penicillin G

Answer 2

IM/IV

renal excretion

Question 3

Penicillinase-Resistant (Methicillin)

Answer 3

po

renal exretion

Question 4

Amoxicillin

Answer 4

po

renal excretion

Question 5

Antipsuedomonal

Answer 5

IV only

renal excretion

Question 6

Cephalexin

Answer 6

po

renal excretion

Question 7

Cefuroxime

Answer 7

po

renal exretion

Question 8

Cefdinir, Ceftiraxone

Answer 8

po

renal exretion

Question 9

Vancomycin

Answer 9

poor oral absorption

renal excretion

Question 10

carbapenems

Answer 10

IV
renal excretion
1 daily + Ertapenem

Question 11

Macrolides

Answer 11

good oral, also IV

concentrates in lungs

Question 12

Azithromycin

Answer 12

good oral, also IV (macrolides)

1 daily, biliary excretion

Question 13

Doxycylcin

Answer 13

po

renal excretion

Question 14

Minocyclin

Answer 14

po

biliary excretion

Question 15

Lincomycins

Answer 15

good po (also IV)

Question 16

Clindamycin

Answer 16

good po (also IV) 
penetrates into bone, hepatobiliary excretion

Question 17

Aminoglycoside

Answer 17

poor oral absorption so IV/IM
accumulates in kidney/ear
extracellular fluid distribution
renal excretion

Question 18

Chloramphenicol

Answer 18

good po (also IV)
metabolizes to CNS/CSF
metabolized by glucuronidation

Question 19

Oxazolidinones

Answer 19

excellent po, also IV

eliminated by non-enzymatic oxidation and renal

Question 20

Streptogamins

Answer 20

IV only

biliary excretion

Question 21

Ciprofloxacin

Answer 21

good oral (also IV)
renal excretion

Question 22

Levofloxacin

Answer 22

good oral (also IV)
renal excretion

Question 23

Nitrofurantoin

Answer 23

good oral (also IV)
rapid GI / kidney absorption so it acts as a urinary antiseptic

Question 24

Metronidazole

Answer 24

good oral (also IV)
hepatic metabolism

Question 25

Sulfamethoxazole/Trimethoprim

Answer 25

``` good po (also IV) hepatic/renal elimation ```

Question 26

Isoniazid

Answer 26

well absorbed orally | metabolized by acetylators

Question 27

Rifampin

Answer 27

well absorbed orally | hepatobiliary excretion

Question 28

Ethambutol

Answer 28

well absorbed orally | renal/fecal excretion

Question 29

Pyrazinamide

Answer 29

well absorbed orally | hepatic metabolism

Question 30

Streptomycin

Answer 30

IM

Question 31

Amphotericin

Answer 31

IV or topical only | slow excretion by kidney/hepatobiliary

Question 32

Nystatin

Answer 32

topical only

Question 33

Caspofungin

Answer 33

IV infusion only | down levels with P450 inducers

Question 34

Fluconazole

Answer 34

po/IV renal excretion enters CNS

Question 35

Terbinafine

Answer 35

po and topical | metabolized by hepatic P450

Question 36

Flucytosine

Answer 36

well absorbed/distributed | renally eliminated

Question 37

Griseofulvin

Answer 37

poor po absorption, give with fatty meal

Question 38

Acyclovir

Answer 38

topical, oral, IV formulations | renal excretion

Question 39

Valacyclovir

Answer 39

renal excretion

Question 40

Entecavir

Answer 40

oral absorption | slow renal excretion

Question 41

Tenofovir

Answer 41

given as pro-drug | excreted by kidneys

Question 42

Interferon-α

Answer 42

parenteral administration | renal elimination

Question 43

Ribavirin

Answer 43

``` aerosol administration, good po long t(1/2) ```

Question 44

Telaprevir, Boceprevir

Answer 44

oral absorption, best with food

Question 45

Sufosbuvir

Answer 45

po w/ or w/out food | renal excretion after inactivation

Question 46

Emtricitabine

Answer 46

orally renal excretion intracellular t(1/2) exceeds plasma t(1/2)

Question 47

Efavirenz

Answer 47

good po | metabolized by/inhibits P450

Question 48

Atazanavir

Answer 48

po metabolized by P450 enzymes DDI with CYP3A4

Question 49

Darunavir

Answer 49

po metabolized by P450 enzymes DDI with CYP3A4

Question 50

Ritonavir

Answer 50

po metabolized by P450 enzymes MOST POTENT CYP3A4 P450 inhibitor

Question 51

Raltegravir

Answer 51

rapid oral absorption | eliminated by hepatic glucouronidation

Question 52

Enfuvirtide

Answer 52

BID SC injection | elim by liver/kidney peptidases

Question 53

Maraviroc

Answer 53

po substrate for CYP3A4 fecal and renal excretion