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D&D Drugs > Drug by Mechanism of Action > Flashcards

Drug by Mechanism of Action Flashcards

1
Q

Penicillins

A

Cell wall synthesis inhibition

(stage 3) bacteriCIDAL

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2
Q

Cephalosporins

A

Cell wall synthesis inhibition

(stage 3) bacteriCIDAL

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3
Q

Vancomycin

A

Cell wall synthesis inhibition

(stage 2) bacteriCIDAL

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4
Q

Carbapenems

A

Cell wall synthesis inhibition

(stage 3) bacteriCIDAL

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5
Q

Macrolides

A

Protein synthesis inhibition (50S)

bacteriostatic

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6
Q

Tetracyclins

A

Protein synthesis inhibition (50S)

bacteriostatic

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7
Q

Lincomycins

A

Protein synthesis inhibition (50S)

bacteriostatic

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8
Q

Aminoglycoside

A

Protein synthesis inhibition (30S)

bacteriCIDAL

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9
Q

Cloramphenicol

A

Protein synthesis inhibition (50S)

bacteriostatic

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10
Q

Oxaxolidinones

A

Protein synthesis inhibition (50S)

bacteriostatic (-CIDAL for Strep)

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11
Q

Streptogamins

A

Protein synthesis inhibition (50S)

[synergistic action results in -CIDAL action against many bacteria]

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12
Q

Fluroquinolones

A

Inhibit DNA gyrase

bacteriCIDAL

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13
Q

Sulfonamides

A

Inhibit folate metabolism

bacteriostatic alone, -CIDAL w/ SMX/TMP

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14
Q

Triazoles

A

Selective inhibition of fungal P450

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15
Q

Imidazoles

A

Inhibit P450 ergosterol synthesis

alters membrane permeability

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16
Q

Influenza drugs

A

Block viral M2 channel to unblock coating
or
Inhibit viral neuraminidase to decrease viral budding)

17
Q

Herpes / CMV drugs

A

phosphorylated viral thmidine kinase inhibits DNA polymerase / chain termination

18
Q

Entacavir

A

guanosine analog

phophory’d to inhibit DNA polymerase [Hepatitis]

19
Q

Tenofovir

A

adenosine nucleotide analog

phophory’d to inhibit DNA polymerase [Hepatitis]

20
Q

Interferon-α

A

inhibits mRNA translation
increased mRNA degradation
virus-specifiv T-cell response [Hepatitis]

21
Q

Ribavirin

A

Inhibits IMP dehydrogenase [Hepatitis]

22
Q

Telaprevir, Boceprevir

A

Prevents formation of the HCV replicase [Hepatitis]

23
Q

Sufosbuvir

A

Nucleotide inhibitor of HCV polymerase [Hepatitis]

24
Q

Reverse Transcriptase Inhibitors (HIV)

A

nucleoside analog that is activated to inhibit viral reverse transcriptase

25
Q

Emitricitabine, Tenofovir

A

HIV meds

nucleotide analog that is activated to inhibit viral reverse transcriptase

26
Q

Nonnucleoside RTI’s , Efavirenz

A

bind to non-catalytic site to inhibit reverse transcriptase

27
Q

Atazanavir, Darunavir, Ritonavir

A

Inhibit viral protease critical for posttranslational protein processing

28
Q

Integrase Inhibitors, Raltegravir

A

Inhibits viral enzyme used for viral genome intertion into DNA

29
Q

Fusion Inhibitors, Enfuvirtide

A

Peptide that prevents HIV fusion with gp41 and cell entry

30
Q

CCR5 Receptor Antagonist, Maraviroc

A

Block of CCR5-tropic HIV-1 into CD4 cells

D&D Drugs (7 decks)

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