Drug by Mechanism of Action

Question 1

Penicillins

Answer 1

Cell wall synthesis inhibition

(stage 3) bacteriCIDAL

Question 2

Cephalosporins

Answer 2

Cell wall synthesis inhibition

(stage 3) bacteriCIDAL

Question 3

Vancomycin

Answer 3

Cell wall synthesis inhibition

(stage 2) bacteriCIDAL

Question 4

Carbapenems

Answer 4

Cell wall synthesis inhibition

(stage 3) bacteriCIDAL

Question 5

Macrolides

Answer 5

Protein synthesis inhibition (50S)

bacteriostatic

Question 6

Tetracyclins

Answer 6

Protein synthesis inhibition (50S)

bacteriostatic

Question 7

Lincomycins

Answer 7

Protein synthesis inhibition (50S)

bacteriostatic

Question 8

Aminoglycoside

Answer 8

Protein synthesis inhibition (30S)

bacteriCIDAL

Question 9

Cloramphenicol

Answer 9

Protein synthesis inhibition (50S)

bacteriostatic

Question 10

Oxaxolidinones

Answer 10

Protein synthesis inhibition (50S)

bacteriostatic (-CIDAL for Strep)

Question 11

Streptogamins

Answer 11

Protein synthesis inhibition (50S)

[synergistic action results in -CIDAL action against many bacteria]

Question 12

Fluroquinolones

Answer 12

Inhibit DNA gyrase

bacteriCIDAL

Question 13

Sulfonamides

Answer 13

Inhibit folate metabolism

bacteriostatic alone, -CIDAL w/ SMX/TMP

Question 14

Triazoles

Answer 14

Selective inhibition of fungal P450

Question 15

Imidazoles

Answer 15

Inhibit P450 ergosterol synthesis

alters membrane permeability

Question 16

Influenza drugs

Answer 16

Block viral M2 channel to unblock coating
or
Inhibit viral neuraminidase to decrease viral budding)

Question 17

Herpes / CMV drugs

Answer 17

phosphorylated viral thmidine kinase inhibits DNA polymerase / chain termination

Question 18

Entacavir

Answer 18

guanosine analog

phophory’d to inhibit DNA polymerase [Hepatitis]

Question 19

Tenofovir

Answer 19

adenosine nucleotide analog

phophory’d to inhibit DNA polymerase [Hepatitis]

Question 20

Interferon-α

Answer 20

inhibits mRNA translation
increased mRNA degradation
virus-specifiv T-cell response [Hepatitis]

Question 21

Ribavirin

Answer 21

Inhibits IMP dehydrogenase [Hepatitis]

Question 22

Telaprevir, Boceprevir

Answer 22

Prevents formation of the HCV replicase [Hepatitis]

Question 23

Sufosbuvir

Answer 23

Nucleotide inhibitor of HCV polymerase [Hepatitis]

Question 24

Reverse Transcriptase Inhibitors (HIV)

Answer 24

nucleoside analog that is activated to inhibit viral reverse transcriptase

Question 25

Emitricitabine, Tenofovir

Answer 25

HIV meds | nucleotide analog that is activated to inhibit viral reverse transcriptase

Question 26

Nonnucleoside RTI's , Efavirenz

Answer 26

bind to non-catalytic site to inhibit reverse transcriptase

Question 27

Atazanavir, Darunavir, Ritonavir

Answer 27

Inhibit viral protease critical for posttranslational protein processing

Question 28

Integrase Inhibitors, Raltegravir

Answer 28

Inhibits viral enzyme used for viral genome intertion into DNA

Question 29

Fusion Inhibitors, Enfuvirtide

Answer 29

Peptide that prevents HIV fusion with gp41 and cell entry

Question 30

CCR5 Receptor Antagonist, Maraviroc

Answer 30

Block of CCR5-tropic HIV-1 into CD4 cells