Drug by Mechanism of Action Flashcards
Penicillins
Cell wall synthesis inhibition
(stage 3) bacteriCIDAL
Cephalosporins
Cell wall synthesis inhibition
(stage 3) bacteriCIDAL
Vancomycin
Cell wall synthesis inhibition
(stage 2) bacteriCIDAL
Carbapenems
Cell wall synthesis inhibition
(stage 3) bacteriCIDAL
Macrolides
Protein synthesis inhibition (50S)
bacteriostatic
Tetracyclins
Protein synthesis inhibition (50S)
bacteriostatic
Lincomycins
Protein synthesis inhibition (50S)
bacteriostatic
Aminoglycoside
Protein synthesis inhibition (30S)
bacteriCIDAL
Cloramphenicol
Protein synthesis inhibition (50S)
bacteriostatic
Oxaxolidinones
Protein synthesis inhibition (50S)
bacteriostatic (-CIDAL for Strep)
Streptogamins
Protein synthesis inhibition (50S)
[synergistic action results in -CIDAL action against many bacteria]
Fluroquinolones
Inhibit DNA gyrase
bacteriCIDAL
Sulfonamides
Inhibit folate metabolism
bacteriostatic alone, -CIDAL w/ SMX/TMP
Triazoles
Selective inhibition of fungal P450
Imidazoles
Inhibit P450 ergosterol synthesis
alters membrane permeability
Influenza drugs
Block viral M2 channel to unblock coating
or
Inhibit viral neuraminidase to decrease viral budding)
Herpes / CMV drugs
phosphorylated viral thmidine kinase inhibits DNA polymerase / chain termination
Entacavir
guanosine analog
phophory’d to inhibit DNA polymerase [Hepatitis]
Tenofovir
adenosine nucleotide analog
phophory’d to inhibit DNA polymerase [Hepatitis]
Interferon-α
inhibits mRNA translation
increased mRNA degradation
virus-specifiv T-cell response [Hepatitis]
Ribavirin
Inhibits IMP dehydrogenase [Hepatitis]
Telaprevir, Boceprevir
Prevents formation of the HCV replicase [Hepatitis]
Sufosbuvir
Nucleotide inhibitor of HCV polymerase [Hepatitis]
Reverse Transcriptase Inhibitors (HIV)
nucleoside analog that is activated to inhibit viral reverse transcriptase
Emitricitabine, Tenofovir
HIV meds
nucleotide analog that is activated to inhibit viral reverse transcriptase
Nonnucleoside RTI’s , Efavirenz
bind to non-catalytic site to inhibit reverse transcriptase
Atazanavir, Darunavir, Ritonavir
Inhibit viral protease critical for posttranslational protein processing
Integrase Inhibitors, Raltegravir
Inhibits viral enzyme used for viral genome intertion into DNA
Fusion Inhibitors, Enfuvirtide
Peptide that prevents HIV fusion with gp41 and cell entry
CCR5 Receptor Antagonist, Maraviroc
Block of CCR5-tropic HIV-1 into CD4 cells