Drawing Gluconeogenesis Flashcards

1
Q

What is the first step in gluconeogenesis and draw it?

A

(2) pyruvate -> (2) oxaloacetate

2ATP -> 2ADP

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2
Q

What is the enzyme that catalyzes pyruvate to oxaloacetate?

A

Pyruvate carboxylase

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3
Q

Draw oxaloacetate

A

(-)O-C(=O)-C(=O)-CH2-C(=O)-O(-)

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4
Q

What is the second step in gluconeogenesis and draw it

A

(2) oxaloacetate -> (2) phosphoenolpyruvate

2GTP -> 2GDP

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5
Q

What is the enzyme for oxaloacetate to phosphoenolpyruvate?

A

PEP carboxykinase

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6
Q

What is step 3 of gluconeogenesis and draw it

A

(2) Phosphoenolpyruvate < > (2) 2-phosphoglycerate

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7
Q

What is the enzyme for phosphoenolpyruvate to 2-phosphoglycerate?

A

Enolase

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8
Q

What is step 4 of gluconeogenesis and draw it

A

(2) 2-phosphoglycerate < > (2) 3-phosphoglycerate

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9
Q

What is the enzyme for 2-phosphoglycerate to 3-phosphoglycerate?

A

Phosphoglycero-mutase

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10
Q

What is step 5 of gluconeogenesis and draw it

A

(2) 3-phosphoglycerate < > (2) 1,3-bisphosphoglycerate

2ATP -> 2ADP

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11
Q

What is the enzyme for 3-phosphoglycerate to 1,3-bisphosphoglycerate?

A

Phosphoglycerate kinase

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12
Q

What is step 6 of gluconeogenesis and draw it

A

(2) 1,3-bisphosphoglycerate < > (2) glyceraldehyde 3-phosphate
2NADH + H+ -> 2NAD+ + 2Pi

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13
Q

What enzyme catalyzes 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphate?

A

Glyceraldehyde 3-phosphate dehydrogenase

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14
Q

What is step 7 of gluconeogenesis and draw it

A

(2) Glyceraldehyde 3-phosphate < > (2) Dihydroxyacetone phosphate

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15
Q

What enzyme catalyzes glyceraldehyde 3-phosphate to dihydroxyacetone phosphate?

A

Triose phosphate isomerase

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16
Q

What is step 8 of gluconeogenesis and draw it

A

(2) Glyceraldehyde 3-phosphate < > Fructose 1,6-bisphosphate

17
Q

What enzyme catalyzes glyceraldehyde 3-phosphate to fructose 1,6-bisphosphate

A

Aldolase

18
Q

What is step 9 of gluconeogenesis and draw it

A

Fructose 1,6-bisphosphate -> fructose 6-phosphate

H2O -> Pi

19
Q

What enzyme catalyzes fructose 1,6-bisphosphate to fructose 6-phosphate?

A

Phosphofructo-kinase-1

20
Q

What is step 10 of gluconeogenesis and draw it

A

Fructose 6-phosphate < > glucose 6-phosphate

21
Q

What enzyme catalyzes fructose 6-phosphate to glucose 6-phosphate?

A

Fructose 1,6-bisphophosphatase

22
Q

What is step 11 of gluconeogenesis and draw it

A

Glucose 6-phosphate -> glucose

H2O -> Pi

23
Q

What enzyme catalyzes glucose 6-phosphate to glucose?

A

Glucose 6-phosphatase

24
Q

Draw formation of oxaloacetate in mitochondria matrix to cytoplasm from pyruvate

A

Pyruvate -> Oxaloacetate -> Malate —–> Malate -> Oxaloacetate
1st part: CO2 + ATP -> ADP + Pi
2nd part: NADH + H+ -> NAD+
malate back to oxaloacetate now in cytoplasm rxn: NAD+ -> NADH + H+