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Pharmacy Technician > Dosage Forms and Routes of Administration > Flashcards

Dosage Forms and Routes of Administration Flashcards

1
Q

dosage form

A
  • the way a drug is identified in its physical form
  • comprised of active and inactive ingredients
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2
Q

Defining Dosage Forms

A
  • Physical appearance of drug product
  • Physical form of drug product prior to dispensing
  • The way a product is administered
  • Dosage frequency
  • How pharmacists and other health professionals might recognize and handle the product
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3
Q

Active Ingredients

A

drugs

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4
Q

inactive ingredients

A

excipients

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5
Q

excipients

A

provide the performance characteristics of the dosage form

  • Can also include:
    • diluents
    • binders
    • granulating agents
    • glidants
    • lubricants
    • disintegrants
    • sweeteners
    • flavors
    • pigments
    • polymer coating
  • Tablets must be strong enough to survive manufacturing, packaging and handling. excipients are important to this requirement
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6
Q

Primary Routes of Administration

A
  • Oral (Enteral)
  • Inhalation
  • Parenteral
  • Topical
  • Suppository
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7
Q

Oral Route

A
  • drug administration that involves taking medication by mouth
  • most convient route for patients
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8
Q

Pills

A
  • 1st solid oral-dosage form
  • many still refer to tablets and capsules as pills
  • date back to 1500 bc
  • 500 bc earliest known trademark on pills with special indentations similar to today’s embossing
  • early pill excipients were:
    • honey
    • bread dough
    • grease
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9
Q

pilula

A

early name for pill

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10
Q

Tablets

A
  • Most common form of solid oral-dosages
    • standard compressed
    • controlled release
    • chewable
    • orally disintegrating
    • coated
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11
Q

tablete

A
  • Old French word from which the word tablet is derived
  • means “little slab”
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12
Q

William Brockedon

A
  • 1844 in England invented compressed tablets
  • (prior to this, they were rolled into long snakes or tubes and cut into “little slabs” = tablets)
  • compressed manufacturing is now the most economical way to produce pharmaceuticals
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13
Q

High-Speed Tableting Machines

A
  • can produce up to 1 million tablets per hour
  • tablet manufacturing bacame high-speed following WWII when bullet manufacturing methods were modified to create tablets
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14
Q

diluents

A

a diluting substance

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15
Q

binders

A

a substance that causes the components of a mixture to cohere

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16
Q

granulating agents

A

a binding agent added to form the fine particles together into granules

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17
Q

glidants

A

flow aids used to maintain efficient movement of bulk powders from hoppers into the tableting press

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18
Q

lubricants

A

used to ensure the tablet is easily ejected from the compression mold

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19
Q

polymer coating

A

makes the tablet more resilient, extends shelf life, improves appearance while making a tablet easier to swallow, and controling how slowly or quickly the active ingredient is released

  • are necessary for medications with an unpleasant taste
  • must not stick together during the coating process
  • must follow the fine contours of embossed characters or logos on the tablet
  • must permit tablets to be permeable enough to eventually disintegrate in the GI tract
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20
Q

Tablet Shapes

A
  • Round, Oval, and Capsule
    • most common shapes
  • Can be made in virtually any shape, however the 3 most common are easiest for patients to swallow and the more uncommon shapes are prone to chipping and breakage during manufacturing, shipping and handling
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21
Q

Tablet Administration

A
  • orally
    • sublingually
    • buccally
    • ODT
  • rectally
  • intravaginally
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22
Q

sublingually

A

under the tongue

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23
Q

buccaly

A

between the cheek and gum

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24
Q

rectally

A

anus administration

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25
Q

intravaginally

A

vagina administration

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26
Q

ODT

A

orally disintegrating tablets

  • designed to break up when the touch saliva - used for the population of patients who have trouble swallowing
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27
Q

caplet

A

a tablet that is smooth, coated, and oval-shaped in the general shape of a capsule

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28
Q

Capsule

A
  • 2nd most common oral-dosage form
  • comprised of a gelatin “shell” and the medicinal “filling”
  • may be hard or soft shelled
  • may be powder, liquid or pellet filled
  • may be coated
  • mayb be banded (against tampering)
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29
Q

capsula

A

Latin word from which the word capsule is derived

  • means “small box or container”
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30
Q

softgels

A
  • were the first capsules
  • invented in 1834 by a French pharmacist
  • invented to mask the unpleasant taste and odor of many medicinal substances
  • today they may be referred to as soft-shelled capsules
  • and ar primarily used for oils and for active ingredients that are dissolvedor suspended in oils (poorly soluble)
  • filling process ensures each softgell has the same amount and concentration of medication
  • prevents operators from being exposed to drug dust, making them well suited for potent medications
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31
Q

James Murdock

A
  • patented the 2-piece gelatin capsule in 1847, in London
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32
Q

hard-shelled capsules

A
  • made using gelatin and contain dry, powdered ingredients, or miniature pellets
  • composed of 2 halves:
    • body
    • cap
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33
Q

pellets

A

a way of controlled release with capsules

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34
Q

body

A

lower diameter shell of the capsule that is filled

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35
Q

cap

A

higher-diameter shell of the capsule that seals the body

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36
Q

capsule size

A
  • variety of sizes
  • 000 = largest
  • 5 = smallest
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37
Q

gelatin

A
  • as related to capsules:
    • made mainly from animal protein
    • similar to Jell-O gelatin
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38
Q

Modern High-Speed Capsule Machine

A

can produce up to 200,000 capsules an hour

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39
Q

Oral Liquids

A
  • 3rd most common oral-dosage form
  • mostly used for pediatric application
  • oldest dosage system for medications
    • history includes ancient elixirs and potions
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40
Q

Oral Liquid Forms

A
  • solutions
  • emulsions
  • suspensions
  • come either finished or in a granular or powder form that must be prepared just before use
  • may be clear, colored, or cloudy
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41
Q

solution

A

a homogeneous, molecular mixture of two or more substances

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42
Q

homogeneous

A

as relates to medication forms, mixed together until the substances are mixed equally; one part of the solution is the same as any other part of the solution should it be divided (into doses, for example).

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43
Q

emulsions

A
  • a dispersion of two insoluble liquids (phases)
  • may settle upon standing with the phases distributed into distinct bands
  • once shaken, the solution will become homogenous for a time.
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44
Q

suspensions

A
  • a dispersion of solid particles in a liquid - usually water
  • will settle upon standing
  • homogeneous when shaken
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45
Q

multi-dose

A

a preparation of liquid medications where a prepared bottle of medicine is intended to be measured out into smaller, equal, sizes for administration

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46
Q

single-dose

A

a liquid medicine preparation where the entire mixture is intended for a one-dose administration

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47
Q

syrups

A

specialy liquid preparations that contain a high proportion of sucrose and are usually very sweet, making them well suited for masking unpleasant tastes and help children tolerate medications

  • syrups have antimicrobial preservatives added since microorganisms grow well in sugar media
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48
Q

elixirs

A

have traditionally been ethanol-containing solutions

ethanol has been used to dissolve a drug substance with poor water solubility

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49
Q

reconstitutions

A

adding water to a dry drug substance

  • many drugs lack water stability and have poor shelf life as a liquid preparation
  • dry powders – such as antibiotics – will remain stable for years and can be reconstituted
  • once reconstituted it becomes a suspension with exp. date of 14 days
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50
Q

microemulsions & nanoemulsions

A

newer forms of emulsion that disperses the insoluble phase into tiny droplets that are suspended in the continuous phase.

  • the droplet size averages from micrometers to nanometers in diameter
  • are clear, and may resemble a solution
  • unlike other emulsions, these will not settle and do not require shaking
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51
Q

“Shake Well Before Use”

A

required labeling for both suspensions and emulsions

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52
Q

Inhalation

A
  • very old method of medication administration
  • primarily used to provide local relief of pulmonary symptoms associated with asthma and COPD
53
Q

nasal inhaler

A

primarily used to treat hay fever and other allergies

54
Q

aerosol therapy

A

becme the mainstay of respiratory care during the 20th century

55
Q

aerosls

A

sprays of small droplets or particles suspended in a gas

56
Q

Inhaler Classes

A

3 Major Classes:

  • dry powder (DPI = dry powder inhaler)
  • nebulizer
  • metered dose
57
Q

DPI

A

dry powder inhaler

58
Q

Aerohaler

A

1950’s was early version of DPI that delivered PCN to treat respiratory infections

59
Q

nebulizer

A
  • dates back to ancient Greece for psychotropic drugs
  • smoked leaves of the Datura ferox plant used to treat asthma in early 1800’s
  • humidifier’s debuted in U.S. in 1949
  • improvements continue
60
Q

MDI

A

metered dose inhaler

  • first approved for clinical use in 1956
  • still widely used today
61
Q

Inhaled Corticosteroids

A
  • also referred to as topical corticosteroids or glucocorticosteriods
  • anti-inflammatory medications that have been used successfully to treat asthma for over 50 years
62
Q

bronchodilators

A

nonsteriod medications that open up airways by relaxing the small muscles that tighten the airways

63
Q

rapid-acting bronchodilators

A

rescue inhaler or quick-relief inhalers

64
Q

aerosol clouds

A

contain particles that are neither too small (risking exhalation) nor too large (tend to deposit primarily in the throat and upper airways)

65
Q

pressurized MDI

A
  • propels medication more deeply into the lungs than a regular inhaler
  • guards against medications being deposited mainly in the throat, mouth and upper airways as is a common problem with regular inhalers and when patients inhale too forcefully with administration
66
Q

spacer

A
  • a divice that may be prescribed if the patient has trouble coordinating the medication delivery of an MDI with the inspiratory process
  • spacer may also make the medication droplets smaller which enables them to be more easily drawn into the lower airways where they are needed
  • some MDI’s have built in spacers
  • some MDI’s are automated to release medication with the patitients inspiration through the inhaler
67
Q

Inhalation Benefits

A

Many manufacturers are working on ways to deliver therapeutic agents by inhalation due to the fact that small molecules deposited in the lungs are very rapidly absorbed systemically due to these factors:

  • huge surface area of the lungs
  • highly dispersed nature of aerosols
  • hundreds of millions of particles per dose
  • good epithelial permeability

rapid absorption causes medication to be fast-acting

68
Q

Parenteral Administration

A

medications administered directly into body tissues rather than through the alimentary canal

  • SQ
  • IM
  • IV
69
Q

alimentary canal

A

digestive system that extends from the mouth to the anus

70
Q

para enteron

A

Greek words from which paraenteral is derived. Para meaning “beside” and enteron meaning “the intestine”

71
Q

SC

A
  • subcutaneous
  • under the skin
72
Q

IM

A
  • intramuscular
  • into the muscle
73
Q

IV

A
  • intravenous
  • into the vein
74
Q

Sir Christopher Wren

A
  • 1st recorded injection of medicine into animals
  • 1657
75
Q

Dr. Alexander Wood

A
  • 1855, performed the first SQ injection using hypodermic needle
76
Q

Baxter

A

produced the first commercially prepared prepared intravenous solution in 1931

intravenous solutions became a mainstay of hospital care by 1950’s

77
Q

nosocomial

A

hospital-acquired infections

78
Q

parenteral advantages

A

Over other administration routes include:

  • it can be used with drugs that are poorly absorbed or ineffective when given orally
  • provides immediate onset of action
  • can be used for slow or delayed drug action
  • assures that a patient has received their dose of medication
79
Q

parenteral disadvantages

A

over other drug administration routes are:

  • costly and painful
  • can be difficult to reverse
  • requires aseptic technique
  • requires special devices, such as infusion pumps
80
Q

Special Injection Routes

A

Used by physicians only:

  • intra-arterial = into an artery
  • intraperitoneal = into organ cavity
  • intracardiac = into the heart
  • intrathecal = into spinal canal
81
Q

deposition site

A

spot in which medication is injected or deposited

82
Q

syrinx

A

Greek word from which we get syringe, means “tube”

83
Q

barrel

A

of the syringe is a tube that is open at one end and tapers to a hollow tip at the other end

84
Q

plunger

A

of a syringe is a tightly fitting rod that seals medication in the barrel and pushes it out the barrel tip as the blunger slides forward

85
Q

tip

A

of a syringe is where the needle attaches to the syringe barrel

86
Q

graduation lines

A

on the sides of the barrel show the volume of syringe solutions in mL’s or fractions of mL’s

87
Q

Luer-Lok

A

common type of syringe tip that incorporates a twist-on coupler that locks the needle onto the barrel and creates a leak-free connection

88
Q

Slip-Tips

A

a common syringe tip that makes needle installation quick and simple. The needle is held on the syringe by friction and is reasonably secure. The needle may come off if not attached correctly or if a lot of pressure used

89
Q

Eccentric Tips

A

are used when a needle must be nearly parallel with the skin. The tip of the syringe is nearly in line with the outer edge of the barrel. enabling the barrel to be in close proximity with the skin. Good for injections into a surface vein.

90
Q

Syringe sizes

A
  • range from 1 - 60 mL’s
  • as a rule, syringes should be selected that are the next size up from the volume to be measured
  • syringes should not be filled to capacity to lessen the chance of the plunger becoming dislodged from the barrel
91
Q

hub

A

of a needle is at the end of the needle and forms the adaptor that connects the needle to the syringe

92
Q

shaft

A

of a needle is the length of metal that ends in the bevel

93
Q

bevel

A

the sharp, pointed end of a needle

94
Q

hollow bore

A
  • lumen
  • hollow space inside the needle shaft
95
Q

Needle size

A

Designated by length and gauge

96
Q

needle length

A

measured in inches from where the hub joins the shaft to the tip of the bevel

  • range from 3/8 inch to 3 1/2 inches
  • some specialty needles are even longer
97
Q

needle gauge

A

refers to the size of the lumen

  • range from 30G (smallest) to 13G (largest)
    • G = gauge
98
Q

needle size factors

A
  1. type and viscosity of solution
  2. nature of the rubber closure on the vial
99
Q

coring

A

occurs when a needle punctures or tears a part of the rubber closure on the vial and the piece falls into the medication causing = particulate material contamination

100
Q

filter needle

A
  • depth needle
  • has a small built-in filter between shaft and hub to remove any particulate matter
  • commonly used with ampules
101
Q

vented needle

A

allows the simultaneous addition of fluid and the vented building up of pressure from constituting a powdered medication

102
Q

transfer needle

A

has a bevel at each end and is used when transferring the entire contents of one vial into another vial

103
Q

parenteral solutions

A

come packaged as LVP solutions and SVP solutions

104
Q

LVP

A

large-volume parenteral

  • typically bags or bottles containing larger volumes (greater than 100 mL’s)
105
Q

SVP

A

small-volume parenteral

  • come in a unit dose container of 100 mL’s or less in a small plastic bag (minibag), ampules, vials, cartridges, and prefilled syringes
106
Q

liquid parenteral drugs

A

are provided in prefilled syringes, heat-sealed ampules, or rubber sealed vials

107
Q

powdered parenteral drugs

A

are provided in vials and they must be constituted before addition to any solution

108
Q

constituted

A

dissolved in a suitable liquid

109
Q

Topical Medications

A

drug applied to body surfaces

  • date to 3000 bc in Ancient Egypt
110
Q

topos

A

Greek word from which topical is derived, means “place” or “location”

topoi = Greek pleural form

111
Q

Topical Applications

A
  • Epicutaneous
  • Ophthalmics
  • Otics
  • Dental
112
Q

Epicutaneous

A

applied directly to the skin

113
Q

ophthalmics

A

(eye drops) applied to the conjunctiva

factoid: eye drop solutions MAY be used in the ear

114
Q

Otics

A

(ear drops) placed in the ear canal

factoid: ear drops MAY NOT be used in the eye because the eye is a sterile field and the ear is not.

115
Q

local effect

A

medication affects only the area to which it’s applied

116
Q

systemic effect

A

when medication affects the entire body system

117
Q

base

A

as relates to medications: is the medium for the drug

the correct base is critical to patient treatment and should never be switched one for another.

118
Q

topical base

A

usually wax or oil

119
Q

potency

A

strength

120
Q

Topical Solutions

A
  • are of low viscosity
  • often use water or alcohol as a base
121
Q

Lotions

A
  • thicker than solutions
  • emollient - moisturizing in nature more than solution
  • usually an oil and water mixture that contains less alcohol than a solution
122
Q

cream

A
  • an emulsion nof oil and water in approx. equal proportions
  • penetrates the stratum corneum
  • thicker than lotion and maintains shape when removed from the container
  • has moderate moisturising qualities
123
Q

stratum corneum

A

outer layer of the skin wall

124
Q

ointments

A
  • homogeneous, viscous, semi-solid
  • generally 80% oil and 20% water
  • very moisturizing
  • unpopular due to greasy/oily application
125
Q

prophylactic

A

disease prevention

126
Q

Gels

A
  • thicker than solution
  • often are a semisolid emulsion in an alcohol base
  • some will melt at body temp
127
Q

Transdermal Patches

A
  • medicated adhesive applications that time-release small amounts of medication into the blood stream through the membrane of the skin
128
Q

Suppository

A
  • rectum
  • vagina
  • urethra
  • deliver systemic and local medications

Pharmacy Technician (21 decks)

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