Dopaminergic Pathways Flashcards
Dopaminergic Pathways
Mesocortical
Mesolimbic
Nigrostriatal
Tuberoinfundibular
Mesocortical course
midbrain ventral tegmental area–>prefrontal
Mesolimbic course
Midbrain ventral tegmental area–>Nucleus accumbens
Nigrostriatal course
midbrain Substantia nigra releases D1 and D2 in the basal ganglia
Tuberoinfundibular
Hypothalamus–>Anterior Pituitary–>Inhibits prolactin
Dopaminergic pathway associated with negative symptoms of schizophrenia from decreased activity
Mesocortical (anergia, apathy, lack of spontaniety)
Dopaminergic pathway associated with positive symptoms of schizophrenia from increased activity
Mesolimbic (hallucinations, delusions)
Dopaminergic pathway associated with extrapyramidal symptoms/Parkinsons
Nigrostriatal pathway (dystonia, akathisia, parkinsonism, tardive dyskinesia)
Dopaminergic pathway associated with hyperprolactinemia
tuberoinfundibular