Doacs

Question 1

Direct Xa inhibitors and renal impairment

Answer 1

Avoid if under 15
Caution if 15-29

Question 2

Dabigatran and renal impairment

Answer 2

Avoid if under 30
Dose reduction if 30-50

Question 3

Can you use apicaban in pregnancy

Answer 3

No

Question 4

Can you use apixaban in breast feeding

Answer 4

No

Question 5

Contraindications of apixaban (3)

Answer 5

Antiphospholipid syndrome- increased risk of recurrant thrombotic events
Prosthetic heart valve
Bleeding risk

Question 6

Apixaban with hepatic impairment

Answer 6

Avoid if severe

Question 7

Which drugs need to be avoided with doacs

Answer 7

Other anticoagulants
Hiv protease inhibitors

Question 8

Which drugs mess up levels of doacs

Answer 8

Cyp3a4 inducers and inhibitors- antifungal, rifampicin, carbemazepine, phenytoin, St John’s wort, macrolides

Question 9

Edoxaban monitoring

Answer 9

Renal function and hepatic function before treatment

Question 10

Rivaroxaban hepatic impairment

Answer 10

Avoid in hepatic disease with coagulopathy and clinically relevant bleeding including moderate to severe cirrhosis