DNA Viruses - Other Flashcards
Which DNA viruses fall into the “other” category?
Adeno, pox, parvo, papilloma, polyoma. (APPPP)
What is unique about the structure of poxvirus?
Pox in a box. Brick-shaped, very large complex DNA organized in a dumbbell shape. Has inner and outer membrane.
Where does poxvirus replicate?
In the cytoplasm. Carries many of its own enzymes.
What three clinical presentations is poxvirus associated with?
Smallpox, cowpox (milkmaid blisters), and molluscum contagiosum.
What are the differences between chickenpox and smallpox?
Smallpox is a poxvirus, not herpesvirus. Lesions look the same but all arise at once (synchronous), and appear most dense on face and palms, and ulcerate much deeper into the skin, leaving permanent scars. Also 30% of ppl with smallpox died.
What are the two main presentations of human papilloma virus?
Warts (1,2,6,11). Cervical cancer (16, 18, 31, 33).
What does the HPV vaccine protect against?
6,11,16,18.
What’s unusual about viral structure of papilloma?
dsDNA is circular. Naked virus!
What’s unusual about the viral structure of polyoma?
dsDNA is circular. Naked virus!
What are the two known polyomaviruses that infect humans?
BK polyoma virus and JC polyomavirus.
What are the manifestations of BK polyoma virus?
BK is ubiquitous and usually causes mild/asx disease in children.
In those with renal Txs, causes nephritis and ureteral stenosis.
In those with bone marrow transplants, cuases hemorrhagic cystitis.
What are the manifestations of JC polyomavirus?
Causes opportunistic infection in immunocompromised patients, classically HIV pts: PML - progressive multifocal leukoencephalopathy.
White matter damage, memory loss, poor speech, incoordination.
What is unique about the structure of adenovirus?
No envelope. Naked!
What are the clinical manifestations of adenovirus?
Febrile pharyngitis (sore throat)
Conjunctivitis
Rhinitis/cough.
Can progress to pneumonia.
What’s the second most common viral cause of endemic diarrhea in infants and children across the world?
enteric adenoviruses.
