DNA viruses - Herpesviridae

Question 1

Which virus is associated with gingivostomatitis, keratoconjunctivitis, herpes labialis?

Answer 1

HSV-1

Question 2

Which virus is associated w/ temporal lobe encephalitis (most
common cause of sporadic encephalitis, can present with altered mental status, seizures, and/or aphasia).

Answer 2

HSV-1

Question 3

How is HSV-1 transmitted?

Answer 3

Transmitted by respiratory secretions, saliva.

Question 4

Which virus is associated with Herpes genitalis, neonatal herpes.

Answer 4

HSV-2

Question 5

How is HSV-2 transmitted? Where does it hang out latent?

Answer 5

Transmitted by sexual contact, perinatally. Latent in sacral ganglia.

Question 6

Which virus is associated with chickenpox, shingles, encephalitis, and pneumonia?

Answer 6

VZV

Question 7

Where does VZV hang out latent?

Answer 7

Latent in dorsal root or

trigeminal ganglia.

Question 8

What is the most common complication of shingles?

Answer 8

Post-herpetic neuralgia.

Question 9

How is VZV transmitted?

Answer 9

Respiratory secretions.

Question 10

Which virus is classically associated with mononucleosis?

Answer 10

EBV (monospot negative). CMV (monospot negative).

Question 11

What are the symptoms of mononucleosis?

Answer 11

Characterized by fever, hepatosplenomegaly, pharyngitis, and lymphadenopathy
(especially posterior cervical nodes).

Question 12

How is EBV transmitted?

Answer 12

Transmitted by respiratory secretions and saliva; also called “kissing disease” since commonly seen
in teens, young adults.

Question 13

How do EBV cells infect cells?

Answer 13

Infect B cells through CD-21.

Question 14

What do the atypical lymphocytes seen on peripheral blood smear w/ EBV represent?

Answer 14

They are not

infected B cells but rather reactive cytotoxic T cells.

Question 15

What does the monospot test detect?

Answer 15

Heterophile antibodies detected by agglutination of sheep or horse
RBCs.

Question 16

What cancers are associated with EBV?

Answer 16

Lymphomas (eg endemic Burkitt lymphoma), nasopharyngeal carcinoma

Question 17

Which virus is associated with retinitis?

Answer 17

CMV

Question 18

Which virus is associated with congenital infection?

Answer 18

CMV

Question 19

Which virus is associated with mononucleosis and a negative monospot test?

Answer 19

CMV

Question 20

What virus has characteristic owl eye inclusions on blood smear?

Answer 20

CMV

Question 21

How is CMV transmitted?

Answer 21

Congenitally, by transfusion, sexual contact, saliva, urine, transplant

Question 22

Which virus is most associated with roseola?

Answer 22

HSV-6, ie “sixth’s disease”. Also HSV-7.

Question 23

What are the symptoms of roseola?

Answer 23

High fevers for several days that can cause seizures, followed by a diffuse macular rash

Question 24

How are HHV-6/HHV-7 transmitted?

Answer 24

Saliva

Question 25

Which virus is associated with dark, violaceous plaques or nodules? What is this disease?

Answer 25

HHV-8. Kaposi’s sarcoma, a neoplasm of endothelial cells.

Question 26

What else can HHV-8 infect, other than kaposi?

Answer 26

GI tract and lungs.

Question 27

How is HHV-8 transmitted?

Answer 27

Sexual contact.

Question 28

How is herpes encephalitis diagnosed?

Answer 28

CSF PCR

Question 29

Viral culture for…?

Answer 29

skin and genitalia.

Question 30

What is a Tzanck smear?

Answer 30

Smear of opened skin vesicle to detect multinucleated giant cells.

Question 31

A positive Tzanck smear is seen in which herpesviridae?

Answer 31

HSV1, HSV2, and VZV.

Question 32

In which herpesviridae are intranuclear inclusions seen?

Answer 32

HSV-1, HSV-2, and VZV.