DNA viruses

Question 1

Herpes Viruses -name them

Answer 1

HSV-1, HSV-2, VZV, EBV, CMV, CMV, HSV-6, HSV7, HSV-8

Question 2

HSV-1

Answer 2

Transmitted: respiratory secretion/saliva
Causes: cold sores, keratoconjunctivitis, herpes labials, temp lobe encephalitis[that can present w/ seizures, AMS, +/- aphasia]

Question 3

HSV-2

Answer 3

Transmitted- sex, perinatal

Causes: herpes genitalis, neonatal herpes, latent in SACRAL ganglia

Question 4

VZV

Answer 4

Transmitted: respiratory secretions
Causes: chickenpox/shingles, encephalitis, PNA.
LATENT in dorsal root ganglion of trigeminal.
Other: most common complication is post-herpetic neuralgia

Question 5

EBV

Answer 5

Transmitted: resp secretion/saliva; “kissing disease”
Causes: MOno-fever, HSMegaly, pharyngitis, and LADenopathy of esp posterior cervical. +monospot
Patho: infects B-cells through CD21–> atypical lymphocytes on peripheral smear BUT NOT B_CELLS but REACTIVE T-cells
**assoc w/ lymphomas (ie Burkitt’s), nasopharyngeal carcinoma

Question 6

CMV

Answer 6

Transmitted: congenitally, transfusion, sex, saliva, urine, transplant
Causes:
Congenital, mono (-monospot), PNA, retinitis.
other: owl like inclusion in infected cells; latent in mOnOnuclear cells

Question 7

HHV6/HHV-7

Answer 7

Transmitted-saliva

Causes-roseola-high fevers for days that can lead to seizures; THEN macular rash

Question 8

HHV-8

Answer 8

Transmission- sexually
Causes: kaposi sarcoma (neoplasm of endothelial cells)–HIV/AIDs, transplant
Cx: dark/violaceous plaques/nodules representing vasc proliferation. +/- GI tract and lungs

Question 9

Hepadnavirus
Enveloped?
Genetic Material structure?
Examples->causes?

Answer 9

• Yes envelope
• Partially DS and circular
• HBV
  causes: chronic/acute hep; not retrovirus but W/ reverse transcriptase

Question 10

Adenovirus
Enveloped?
Genetic Material structure?
Examples->Causes?

Answer 10

• No
• DNA/linear
• febrile pharyngitis, sore throat, acute hemorrhagic cystitis, PNA, conjunctivitis

Question 11

Parvovirus
Enveloped?
Genetic Material structure?
Examples->Causes?

Answer 11

• No
• SS/linear (smallest DNA virus)
• B19 virus
• sickle cell disease-aplastic crisis in
• Children-slapped cheeks rash (children-erythema infectiosum of 5th disease0
• Fetus-RBC destruction =hydrops fettles and death
• Adults -RBC aplasia and rheumatoid arthritis-like sx’s

Question 12

Papillomavirus
Enveloped?
Genetic Material structure?
examples->Causes?

Answer 12

-No
-Ds/circular
-HPV
warts (1,2,6,11), CIN, cervical cancer (16.18)

Question 13

Polyomavirus
Enveloped?
Genetic Material structure?
examples->Causes?

Answer 13

-No
-DS/circular
-JC virus-> PML in HIV
-BK virus-> transplant patients–commonly kidneys-(hipsters don’t drink enough water in BK, ruin their kidneys)
“junky cerebrum; Bad kidney”

Question 14

Poxvirus
Enveloped?
Genetic Material structure?
Causes?

Answer 14

• Yes
• DS/linear (largest DNA virus)
• Smallpox-live virus, eradicated.
• Cowpox- “milmaid blisters”
• Molluscum -flesh colored with central umbilication

Question 15

HSV -detection

Answer 15

Viral culture for skin/genitals
CSF-PCR
Tzanck smear-open skin vesicle–> HSV1, 2, VZV that have giant cells. Intranuclear inclusions also in HSV-1,2,VZV.