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DNA viruses Flashcards

1
Q

Adenoviridae was 1st isolated in?

A

adenoid tissue

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2
Q

True or False:

Adenoviridae is an enveloped, icosahedral, dsDNA

A

(FALSE)

Naked

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3
Q

Size of adenoviridae

A

70-90nm

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4
Q

Common serotypes of adenoviridae

A

1, 8, 11, 21, 35, 37, 40

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5
Q

Serotype of adenoviridae that is commonly associated with Gastroenteritis

A

40, 41

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6
Q

True or False:

Serotype 4 of adenoviridae causes ARD

A

(FALSE)

Serotype 14

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7
Q

Serotypes 40 and 41 of adenoviridae are also known as

A

Enteric adenoviruses

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8
Q

This is a prominent feature of enteric adenoviruses

A

Diarrhea

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9
Q

This virus is identified but not serotyped by EIA

A

Adenoviridae serotype 40 & 41

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10
Q

True or False:

Adenoviruses are stable

A

True

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11
Q

This virus produces a grapelike cluster cytopathic effect

A

Adenoviridae

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12
Q

HHV-3 is also known as

A

Varicella-Zoster virus

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13
Q

HHV-4 is also known as

A

Epstein-Barr virus

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14
Q

HHV-5 is also known as

A

Cytomegalovirus

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15
Q

HSV-1 & 2 belong to what genus?

A

Simplexvirus

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16
Q

2 categories of herpes simplex virus

A

Primary

Recurrent

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17
Q

5 types of herpes infections

A 
Oral herpes
Genital herpes
Neonatal herpes
HSV-Encephalitis
Ocular herpes
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18
Q

True or False:

Neonatal herpes is more severe when HSV-1 is involved

A

(FALSE)

HSV-2

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19
Q

It is the leading cause of fatal sporadic encephalitis in United States

A

HSV

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20
Q

What treatment is used for HSV-Encephalitis

A

IV antiviral treatment

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21
Q

It is also known as the HSV of the conjunctiva

A

Ocular herpes

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22
Q

What is required for a culture-confirmed diagnosis of Encephalitis

A

Brain biopsy material

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23
Q

It replicates rapidly and cytopathic effect can be seen within 24 hours

A

HSV

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24
Q

What is the antibody used to type HSV

A

Monoclonal antibodies

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25
Q

Old tests for HSV uses _______ preparations from lysed cell culture of the virus

A

Crude antigen

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26
Q

New tests for HSV uses recombinant or affinity purified __________ glycoprotein

A

type-specific

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27
Q

ELVIS test is known as

A

Enzyme-linked, virus-inducible system

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28
Q

Baby hamster kidney cells are used for this test

A

ELVIS test

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29
Q

What color is formed in ELVIS test

A

Blue

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30
Q

Most common congenital infection in United States

A

Cytomegalovirus

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31
Q

Virus that spreads easily in crowded populations

A

CMV

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32
Q

True or False:

In a symptomatic CMV patient, there is an infectious mononucleosis-like illness

A

(FALSE)

Asymptomatic

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33
Q

When is CMV best confirmed in infants?

A

first 2 weeks of life

34
Q

In CMV, after how many weeks does CPE appear?

A

3 weeks

35
Q

This test is based on the detection of 65-kDa and Lower-matrix phosphoprotein

A

Viral antigenemia test

36
Q

This virus belongs to the genus Lymphocryptovirus

A

Epstein-Barr virus

37
Q

Cancers associated with EBV

A

Burkitt lymphoma
Hodgkin disease
Nasopharyngeal carcinoma

38
Q

Where can EBV be recovered?

A

Oropharynx

39
Q

This virus can be transmitted via infected saliva

A

EBV

40
Q

True or False:

In EBV, young children are always symptomatic

A

(FALSE)

Asymptomatic

41
Q

the cell targeted by EBV

A

B lymphocytes

42
Q

Antibodies produced due to EBV

A

Heterophile antibodies

43
Q

This is an excellent rapid screening test for heterophile antibodies

A

Paul-Bunnel heterophile antibody test

44
Q

It is also known as the reactivation of VZV

A

Shingles

45
Q

Cytopathic changes in VZV is evident for how many days

A

3-7 days

46
Q

The standard test for diagnosis of VZV

A

PCR

47
Q

Which variant is common cause of HHV-6

A

Variant B

48
Q

The most likely route of transmission of HHV-6

A

Saliva

49
Q

Serology is not helpful in the diagnosis of HHV-6 unless _________ are available

A

Paired sera

50
Q

When can IgM be detected in HHV-6?

A

5 days after incubation

51
Q

2 tests that is most sensitive and specific for diagnosing primary HHV-6

A

PCR

Viral load testing

52
Q

The receptor for HHV-7

A

CD4

53
Q

True or False:

HHV-7 occurs later in life than HHV-6

A

TRUE

54
Q

This virus belongs to the genus Rhadinovirus

A

HHV-8

55
Q

HHV-8 is also known as

A

Kaposi sarcoma-associated herpesvirus

56
Q

HHV-8 is usually transmitted by ________ contact in North America and Europe

A

Sexual contact

57
Q

The pattern of infection of HHV-8 is similar to what virus

A

HSV-2

58
Q

This virus is associated with common warts and cervical cancer

A

Papillomaviridae

59
Q

What do you use for rinsing Cervical HPV lesions?

A

5% acetic acid

60
Q

Cells that are indicative of HPV infection

A

Koilocytes

61
Q

Condylomata acuminata is also known as

A

Genital warts

62
Q

2 types of HPV that causes majority of cervical cancers

A

Type 16 & 18

63
Q

Used for the detection of HPV DNA

A

Nucleic acid probes

64
Q

Largest DNA virus

A

Poxviridae

65
Q

Brick-shaped virus

A

Poxviridae

66
Q

Variola virus belongs to what genus

A

Orthopoxvirus

67
Q

Variola virus causes what disease?

A

Smallpox

68
Q

Virus that has synchronous progressive rash w/ fever

A

Variola virus

69
Q

Macular rash progress into _______

A

Pustules

70
Q

He demonstrated the efficacy of vaccination against smallpox

A

Edward Jenner

71
Q

This virus was introduced by rodents imported from Africa

A

Monkeypox virus

72
Q

Smallest DNA virus

A

Parvoviridae

73
Q

Principal pathogen in Parvoviridae

A

Parvovirus B19

74
Q

The initial viral isolate of parvovirus B19 was observed using?

A

Electron microscope

75
Q

Also known as fifth disease

A

Erthema infectiosum

76
Q

Virus that gives a slapped cheek appearance

A

Parvovirus B19

77
Q

This virus is characterized by a decrease in RBC production in the Bone marrow

A

Parvovirus B19 Viremia

78
Q

This occurs within 1 week of patients with Parvovirus B19 Viremia

A

Reticulocytosis

79
Q

Novel parvovirus

A

Human Bocavirus

80
Q

Human Bocavirus occurs as a co-infection with ____ & ____

A

RSV (Respiratory scytial virus)

Human metapneumovirus

MV (5 decks)

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