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DNA Virus Flashcards

1
Q

Naked icosahedral

Single-stranded linear DNA virus

A

Parvovirus

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2
Q

ERYTHEMA INFECTIOSUM (FIFTH DISEASE)

A

Parvovirus

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3
Q

APLASTIC CRISIS

A

Parvo Virus

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4
Q

 Second trimester: Hydrops Fetalis

A

Parvo Virus

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5
Q

can be used with aplastic crisis

A

IVIG

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6
Q

acute hemorrhagic cystitis

A

Adenovirus

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7
Q

Cowdry type B intranuclear basophilic inclusion bodies

A

Adenovirus

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8
Q

Naked icosahedral

Double-stranded circular DNA

A

HPV

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9
Q

Naked icosahedral

Double-stranded circular DNA

A

Papovaviridae

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10
Q
  • Infect squamous cells and induce formation of cytoplasmic vacuole (koilocytes)
A

HPV

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11
Q

verruca vulgaris

A

HPV 1,2,3,4

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12
Q

Genital warts (condyloma acuminata

A

HPV 6,11

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13
Q

Most common viral STD

A

HPV Condyloma Acuminata HPV 6,11

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14
Q

Carcinoma of the cervix, vulva, penis, anus

A

HPV 16,18,31,33

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15
Q

Genital warts DOC

A

Podophylin

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16
Q

Skin warts DOC

A

Liquid Nitrogen

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17
Q

Plantar Warts DOC

A

Salicylic acid

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18
Q

small, round, deeply basophilic nuclei surrounded by a clear

halo and pale-staining cytoplasm

A

Koilocytes - HPV

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19
Q

progressive multifocal leukoencephalopathy in patients with AIDS

A

JC Polyoma v.

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20
Q

 Demyelinating disease that affects the oligodendrocytes characterized by deficits in speech, coordination, and memory

A

rogressive multifocal leukoencephalopathy -> JC Polyoma v

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21
Q

hemorrhagic cystitis and nephropathy in patients with solid organ (kidney) and bone marrow transplants

A

BK Polyoma v. (BK - Bladder and Kidney)

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22
Q

Decoy cells

A

Bk Polyoma

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23
Q

HSV 1 Transmission

A

Saliva/ Direct

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24
Q

HSV 2 Transmission

A

Sexually transmitted

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25
Q

TORCH

A

HSV 2 - Neonatal Hepres

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26
Q

Temporal lobe encephalitis

A

HSV 1

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27
Q

Site of Latency HSV 1

A

Trigeminal Ganglia

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28
Q

Site of Latency HSV 2

A

Lumbosacral Ganglia

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29
Q

HSV Tszanck

A

Tzanck smear: multinucleated giant cells

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30
Q

Cowdry Type A:

Cowdry Type B:

A

Type A: HSV, VZV

Type B: Adeno

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31
Q

DOC HSV

A

Acyclovir - only shortens duration and decreases shedding

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32
Q

the most common cause of sporadic, fatal encephalitis in the USA

A

HSV 1

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33
Q

VZV Latent site

A

Dorsal root ganglia

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34
Q

dewdrop on a rose petal appearance’

A

VZV

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35
Q

begins on trunk; spreads to face and extremities (centrifugal)

A

Varicella

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36
Q

Complications Varicella

A

 Complications: Pneumonia, Encephalitis, Reye’s syndrome (Asrpirin also)

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37
Q

most common complication of Herpes Zoster/ Shingles

A

Poestherpitic neuralgia

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38
Q

 Reactivation of latent VZV residing within geniculate ganglion

A

Ramsay Hunt/ Herpes Zoster Oticus

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39
Q

Ramsay Hubt Triad

A

ipsilateral facial paralysis, ear pain, and vesicles on the face

40
Q

Cicatrix

A

Congenital Varicella - 6-12 weeks AOG

41
Q

Varicella DOC

A

Given within 24 hours to severe cases only

42
Q

Ramsay Hunt

A

Valcyclovir + Prednisone

43
Q

Active Varicella Vaccine

A

given within 5 days

44
Q

Anti VZV Ig

A

96 h after exposure

45
Q

o Impair assembly of the MHC class 1-viral peptide complexes

A

Immediate early proteins of CMV

46
Q

 Most common infectious cause of congenital abnormalities

47
Q

 Most common intrauterine viral infection

48
Q

CMV Most common when the mother is infected

A

1st Trimester

49
Q

HETEROPHIL-NEGATIVE MONONUCLEOSIS

50
Q

 AIDS retinitis

51
Q

Giant cells with owl’s-eye nuclear inclusion

52
Q

DOC CMV

A

Gangcylovir

53
Q

DOC for prevention of CMV disease in solid-organ transplant patients is

A

Valgancyclovir

54
Q

Lymphoid and B lymphocytes tgrough CD21

55
Q

INFECTIOUS MONONUCLEOSIS

A

Eeeeepstein Bar EEEnfectious Mono

56
Q

Kissing disease’

A

Epstein Bar

57
Q

Heterophil Positive Mononucleosis

58
Q

Rare complication of Infectious Mono

A

splenic rupture is a rare complication (Avoid contact sports!)

59
Q

EBV Malignancies

A

Burkitt’s lymphoma - Africans <3
Nasopharyngeal CA - Chinese
Hairy Leukoplakia - AIDs

60
Q

elevated “atypical lymphocytes”  Downey cells

61
Q

Use of this antibipotic in mononucleosis can cause characteristic maculopapular rash

A

Amoxicillin

62
Q
  • rose-colored macules appear on body after several days of high fever; can present with febrile seizures; usually affects infants
A

Roseola/ HHV 6

63
Q

erythematous papules on soft palate and base of the UVULA

A

Nagayama Spots - HHV6

64
Q

 most common AIDS-related malignancy

A

Kaposi Sarcoma - HHV 8

65
Q

Kaposi Sarcoma - HHV 8 Tx

A

Surgical excision

Radiation

66
Q

Largest DNA Virus

67
Q

Variola Virus

68
Q

Brick-shaped poxvirus

69
Q

 Lesions with same stage of development

A

Variola - Small Pox (Compare to chicken pox -> with different stages)

70
Q

lesions may become umbilicated or confluent

71
Q

Cenntrifugal rash

A

Small Pox, Chicken Pox

72
Q

Beau’s Lines

A

Kawasaki Disease

73
Q

Centripetal

A

Rocky Mountain Spotty Fever

74
Q

Guarnieri Bodies

75
Q

 flesh-colored dome-shaped papules with central umbilication

A

Moluscum contagiosum

76
Q

Henderson-Patterson bodies:

A

Moluscum Contagiosum

77
Q

Moluscum Contagiosum DOC

78
Q

DOC Smallpox

A

Tecovirimat

79
Q

incomplete circular double-stranded DNA

80
Q
  • the only DNA virus that produces DNA by reverse transcription with mRNA as the template; not a retrovirus but has reverse transcriptase
81
Q
  • hepatocellular injury due to immune attack by cytotoxic T cells
     HBV has no cytopathic effect
82
Q

used as marker of potential infectivity

83
Q

Extrahepatic Manifestations of Hepa B

A

Aplastic Anemia
MPGN
Polyarteritis Nodosa

84
Q

eosinophilic globule of cells that represents a dying hepatocyte often surrounded by normal parenchyma

A

Councilman Body - Hepa B

85
Q

Granular eosinophilic “ground glass” appearance IN Liver Biopsy

86
Q

HBsAg, IgM anti-HBc

A

Acute Infection

87
Q

HBsAg, IgG anti-HBc

A

Chronic Infection

88
Q

HBeAg, HBV DNA

A

Markers of Replication

89
Q

DOC Hepa B

A 
LATE
Lamivudine
Alpha Interferon
Tenofovir
Entecavir
90
Q

HBsAg, HbeAg

A

Incubation Period

91
Q

HBsAg, HbeAg, IgM

A

Acute Infection

92
Q

Only IgM positive

93
Q

Anti HBs, IgG

A

Complete Recovery

94
Q

HBsAg, IgG

A

Chronic Carrier

95
Q

HBsAg, IgG, HbeAg

A

Chronic Active

96
Q

Anti HBs Only

A

Vaccinated

Microbiology (7 decks)

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