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Pharmacology > DNA Gyrase Inhibitors > Flashcards

DNA Gyrase Inhibitors Flashcards

1
Q

Biggest draw back of flouroquinolone

A

Clostridium difficile infection
Bacterial resistance

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2
Q

Eg of flouroquinolone resistance

A

Methicillin resistance in staphylococcus aureus

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3
Q

Normal absorption of flouroquinolones.

A

Norfloxacine - 35-70%
Other - 80-90%

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4
Q

Products which reduces the abs. Of flouroquinolones

A

Dairy, Mg and Al antacids, Ca and other divalent ions…

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5
Q

Safe drug in renal compro. Patient

A

Moxi-floxacin

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6
Q

MOA of flouroquinolones

A

Topoisomerase 2 and 4 inhibition
Inhibition of 2… Relaxation of SUPER COILED DNA….. Inhibition of DNA breakage…

Inhibition of 4 effect chromosomal stability and inhibition of DNA replication

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7
Q

Flouroquinolones spectrum

A

E.coli, haemophillus influenza pseudomonas aeruginosa
Legionella species
Clamidial species

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8
Q

Respiratory flouroquinolones

A

Levo floxacin and maxi floxacin

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9
Q

Example of 1st gen flouroquinolones

A

Nali dixic acid

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10
Q

Use of 1st gen flouroquinolones

A

Urithriris
Prostatitis
Infectious diarrhea

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11
Q

Eg of 2nd gen flouroquinolones

A

Ciprofloxacin, norfloxacine

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12
Q

Use of 2nd gen flouroquinolones

A

GIT , Cystis fibrosis in children, TB, Diarrhea, fever , against gram negative

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13
Q

Eg of 3rd gen flouroquinolones

A

Levo floxacin

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14
Q

Use of 3rd gen flouroquinolones

A

Against gram +, Skin infections, community acquired infections

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15
Q

Eg of 4th gen flouroquinolones

A

Moxi floxacin

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16
Q

Use of 4th gen flouroquinolones

A

Against gram+..
Against anaerobes such as bacteroids fragillis species..

17
Q

Common ADRs of Flouroquinolones

A

…… Phototoxicity , Hypo , hyper glycaemia,

18
Q

1 Contra. Of flouroquinolones

A

Can cause convulsions so carefully used in epileptic patient..

19
Q

Most significant ADRs of Ciprofloxacin

A

Articular cartilage errosion. So shouldn’t be given to pregnant women and children

20
Q

Biggest SE of Moxi-floxacin

A

Prolongation of QT phase so should be avoided in patients with heart condition…

21
Q

Resistance of Flouroquinolones

A

Alteration of target site, Decrease accumulation

Pharmacology (11 decks)

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