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Pharmacology > Anti-harmonal > Flashcards

Anti-harmonal Flashcards

1
Q

What is Tamoxifen

A

Competitive inhibitors of estradiol which binds to estrogen receptor…

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2
Q

MOA of Tamoxifen

A

Change the shape of 3 dimension estrogen receptor…

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3
Q

Effect of estrogen on tumor cells..

A

Increase tumor cell production of transforming growth factor beta ..
Which decreases autocrine stimulation of breast cancer growth…

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4
Q

Effect of Tamoxifen on insulin like growth factor 1

A

Decrease the production of insulin like growth factor 1

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5
Q

Uses of Tamoxifen

A

Slow down osteoporosis
Effective for breast cancer
Progesterone resistant endometrial cancer
Decrease the risk of myocardial infarction

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6
Q

Main toxicities by Tamoxifen

A

Menstrual irregularities
Vaginal Bleeding..

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7
Q

Anti androgens are most effective in which cancer

A

Prostate Cancer treatment

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8
Q

2 Types of Anti androgens

A

Steroidal and non steroidal

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9
Q

Example of steroidal anti androgens

A

Cyproterone acetate, Megestrol acetate

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10
Q

Example of non steroidal anti androgens

A

Flutamide, Nalutamide,

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11
Q

What are steroidal anti androgens

A

Weak partial agonists and competitive inhibitors of androgen receptors…

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12
Q

ADRs

A

Loss of libido, decrease sexual potency and low testosterone level

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13
Q

Role of NSAA

A

Block the translocations of androgen receptor from cytoplasm to nucleus of cell… And induce anti proliferating effect…

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14
Q

ADRs of NSAA

A

Diarrhea, emesis, reversible liver abnormalities

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15
Q

Why neoplastic cell can’t produce L-Asparagine

A

They lack asparagine synthase enzyme so they take it form plasma…

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16
Q

How L-Asparaginase works…

A

They convert asparagine synthetase into aspartic acid and ammonia…

17
Q

How L-Asparaginase is used for the treatment of lymphoblastic leukemia…

A

In combination with methotrexate or vincristine with prednisolone

18
Q

How resistance against L-Asparaginase is developed

A

Induction of asparagine synthetase

19
Q

Toxicities of L-Asparaginase

A

Hypersensitivity, hyperglycaemia, hypertriglyceridemia,. Pancreatitis

20
Q

Hydroxyurea target which phase

A

S phase of cell

21
Q

MOA of Hydroxyurea

A

Act on Ribonucleoside diphosphate reductase which converts Ribonucleoside to deoxy Ribonucleotide

22
Q

Use of Hydroxyurea

A

Thrombocytosis, mylo-proliferative syndrome, chronic granulocytic leukemia, polycythemia Vera,
Sickle cell disease

23
Q

Hydroxyurea potentiate anti proliferative effect of which agent

A

Cisplatin, Alkylating agents and topoisomerase 2 inhibitors…

24
Q

Hydroxyurea toxicities

A

Hematopoietic depression, leukopenia, megaloblastic anemia, teratogenic…

Pharmacology (11 decks)

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