Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Anti Protozoal Drugs > Flashcards

Anti Protozoal Drugs Flashcards

1
Q

4 Classes of Protozoa

A

Sarcodina
Sporozoa
Mastigophora
Ciliophora

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

2 species of Sarcodina

A

Antamoeba histolytica
Diantamoeba fragillis…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

2 species of sporozoa

A

Plasmodium
Toxoplasma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

3 species in mastigophora

A

Trypanosoma
Giardia
Trichomonas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

1 specie in Ciliophora

A

Balantidium Spp

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is Amoebiasis

A

Amoebic dysentry , frequent flow of water stools contains blood and mucus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Two types of Amoebiasis

A

Amoebic hepatitis - Local infarction in liver
Amoebic abscess - Necrosis in liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How antamoeba histolytica cause anemia

A

By engulfing erythrocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Two forms of antamoeba histolytica

A

Non-Cyst form - non-infective
Cyst form is infectious

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

MOA of E. Histolica

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Two classes of drugs for Amoebiasis

A

Tissue amoebisides
Luminal amoebisides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Drugs of tissue amoebisides

A

Nitrioimidazole
Tinidazole
Ornidazole
Metronidazole
Emetine, dehydroemetine, chloroquine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Antibiotics

A

Tetracycline
Erythromycin and paromomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Metronidazole is effective against

A

E.histolica, Trichomonas vaginalis, Giardia lamblia, Balantidium Spp,,

Peptococcus, peptostreptococcos , Clostridium

Hypoxic cells…

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Uses of Metronidazole

A

Amoebiasis
Ulcerative Gingivitis
Trichomonas and Giardial infections with antibiotics
Also used to prevent post operative anaerobic infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

MOA of Metronidazole

A

Nitro group accept electrons from ETP…
Reduced intermediate products
Attack proteins and DNA…..

17
Q

ETP in amoeba and in mammals

A

Feriidoxin, flavoproteins…

18
Q

How metronidazole clearance Is decreased

A

Metronidazole + Cimetidine

19
Q

ADRs of Metronidazole

A

Pruritis, metallic taste, disulfiram like effect

20
Q

Drug of choice in emetine and dehydroemetine

A

Dehydroemetine has less ADRs

21
Q

MOA of emetine

A

Directly effect protein synthesis
Kill trophoziotes in intestine..

22
Q

ADRs of emetine

A

ECG abnormalities
Tachycardia
Arrythmia
Muscular weakness

23
Q

Diloxanide furoate is used for

A

Asymptotic intestinal infections…

24
Q

Diloxanide furoate hydrolysed into

A

Diloxanide - 90% is absorbed and excreted from body through glucuronide conjunction
10% act as luminal amoebisides

Furoic acid

25
Q

ADRs of Diloxanide furoate

A

Flatulence, abdominal cramps..

26
Q

Idoquinol is used as

A

Luminal amoebisides

27
Q

Hydrolysation of Idoquinol

A

Opposite to diloxanide furoate

28
Q

Idoquinol is used with

A

Tetracycline
650+250

29
Q

ADRs of Idoquinol

A

Neurotoxicity and peripheral neuropathy

30
Q

Paromomycin belongs to

A

Aminoglycosides…

31
Q

Uses of Paromomycin

A

Mild to moderate intestinal infections
Effective against trophoziotes inhibition of protein synthesis and genetic code misreading

Pharmacology (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions