DNA and chromosomes Flashcards
gene
segment of DNA that encodes for a protein
chromsome
continuous piece of DNA
Watson and Crick
DNA double helix
Chargaff’s Rule
A=T & G=C
A+G=T+C
phosphodiester bonds
5’ joined to 3’
DNA/RNA composition
- one base
- sugar (deoxyribose or ribose)
- a phosphate
nucleoside
base + pentose
nucleotide
base + pentose +phosphate
B-DNA
normal form of DNA
-right handed
Z-DNA
Zigzag, left-handed
-longer and thinner than B-DNA
A-DNA
right-handed
- shorter and thicker than B-DNA
- made artificially by dehydrating B-DNA
topoisomerases
enzymes that regulate the over-winding or under-winding of DNA
positive supercoiling
tight winding of the double helix
-reduces chances of interaction
negative supercoiling
unwinding of the double helix
-increases access to proteins involved in replication or transcription
genome
one complete copy of all the genetic information of an organism
microsatellites
repeats of sequences less than about 2-6 bp in length
mini satellites
involve repeating of longer blocks 10-60 bp
tandem repeats
pattern if 2+ nucleotides repeated directly beside each other
LINEs
long interspersed nuclear elements
-contain genes required for their own mobilization
SINEs
short interspersed nuclear elements
-rely on enzymes from elements to move them