DMT2 MOAs Flashcards by Hannah Lawrence | Brainscape

Q

Biguanides

Metformin

A

***Inhibits glucose production by decreasing hepatic glucogenesis
Increases tissue sensitivity to insulin

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Q

Sulfonylureas

Glimepiride, Glipizide, Glyburide

A

-Increases insulin production from beta cells in the pancreas (secretagogue)

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Q

DDP-IV Inhibitors

Sitagliptan, Saxagliptan, Linagliptin, Alogliptin

A

-INCRETIN mimetic

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Q

GLP-1 Analogs

Exenatide, Liraglutide

A

-INCRETIN mimetic

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Q

SGLT-2 Inhibitors

Canagliflozin

A

HAS NOTHING TO DO WITH INSULIN!!
Works in the kidneys (pt w/DM have more SGLT-2 receptors)
Inhibits the transport of glucose back into the body –> excreted in urine**

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