Anticoagulant Agents Flashcards
1
Q
Heparin MOA
A
potentiates antithrombin III (inhibits conversion of fibrinogen to fibrin)
2
Q
Heparin Monitoring
A
PTT (in pts = intrinsic pathway)
3
Q
Heparin SEs
A
*Heparin induced thrombocytopenia (HIT)
4
Q
Heparin Antidote
A
Protamine Sulfate
5
Q
LMWH
A
- Enoxaparin (Lovenox)
- Dalteparin (Fragmin)
6
Q
LMWH MOA
A
- ***inactivates factor Xa
- potentiates antithrombin III (inhibits conversion of fibrinogen to fibrin)
7
Q
LMWH Monitoring
A
-none (longer 1/2 life = 12 hrs)
8
Q
LMWH SEs
A
-thrombocytopenia (< than UFH)
9
Q
LMWH CI/Cautions
A
- Renal failure
- not as easily reversible as Heparin
10
Q
Thrombin Inhibitors
A
- Dabigatran
- Argatroban
11
Q
Thrombin Inhibitors MOA
A
Directly inhibits thrombin
12
Q
Thrombin Inhibitors Indication
A
1st line tx for HIT
13
Q
Factor X Inhibitors
A
- Fondaparinux
- Rivaroxaban
- Apixaban
14
Q
Factor X Inhibitors MOA
A
Selective factor Xa inhibitor
