Antihypertensives Flashcards
1
Q
HCTZ MOA
A
Prevents Na/water reabsoprtion at DISTAL DILUTING TUBULE
2
Q
HCTZ Indications
A
- **1st line HTN
- edema
3
Q
HCTZ SEs
A
- *Hyponatremia
- Hypercalcemia
- Hpokalemia
- ***HYPERURICEMIA & HYPERGLYCEMIA
4
Q
HCTZ CI
A
allergy to sulfonamides
5
Q
Loop Diuretics MOA
A
Inhibit transport across ASCENDING limb in LOOP of HENLE -Strongest class of diuretics
6
Q
Loop Diuretics Indications
A
- CHF
- HTN
7
Q
Loop Diuretics SEs
A
- volume depletion
- hypokalemia
- metabolic alkalosis
- hyperglycemia
8
Q
Loop Diuretics CI
A
allergy to sulfonamides
9
Q
Potassium Sparing Diuretics MOA
A
inhibit aldosterone-mediated Na/H20 absorption (spares potassium)
10
Q
Potassium Sparing Diuretics SEs
A
- hyperkalemia
* *gynecomastia w/sprinolactone
11
Q
ACE-I MOA
A
Decreased synthesis of AGII/aldosterone production
12
Q
ACE-I SEs
A
- cough & angioedema d/t increased bradykinin*8
- hyperkalemia (NO K supplements)
13
Q
ARB MOA
A
Blocks effects of AGII (not synthesis)
14
Q
Alpha-1 Blockers
A
- Prazosin
- Terazosin
- Doxazosin
15
Q
Alpha-1 Blockers Indications
A
- HTN
- BPH
- *use if both coexist!
