DM2 Meds

Question 1

Biguanide/Metformin (Glucophage)

Answer 1

Decreases hepatic gluc output
Decreases insulin resistance
Increases peripheral gluc utilization

Question 2

Sulphonylureas: Glipizide (Glucotrol)
Glyburide (Micronase)
Glimepepiride (Amaryl)

Answer 2

Directly increases insulin secretion

Stimulates beta-cells by closure of K+ATP channels

Question 3

DPP-4 Inhibitors: Sitagliptin (Januvia)

Answer 3

Decreases gastric emptying

Increases GLP-1

Question 4

Thiazolidinedoines: Pioglitazone (Actos)

Rosiglitazone (Avandia)

Answer 4

Increases peripheral insulin sensitivity
Increases adipogenesis
Decreases hepatic glucose production

Question 5

SGLT-2: Canaglilozin (Invokana)

Empagliflozin (Jardiance)

Answer 5

Blocks activity of Na glucose transport proteins in kidney
Decreases glucose uptake
Increases glucose secretion in urine

Question 6

Alpha-Glucose Inhibitors: Acarbose (precose)

Miglitol (Glyset)

Answer 6

Slows digestion of CHO in small intestine

Decreases peak BG levels by delaying CHO absorption

Question 7

Amylin Analogue: Pramlintide

Answer 7

Decreases glucagon secretion
Slows gastric emptying
Increases satiety

Question 8

GLP-1 Receptor Agonist: Exenatide (Byetta)

Answer 8

Increases insulin secretion
Slows rate of gluc absorption
Decreases postprandial secretion
Increases satiety