DM2 Medications

Question 1

Metformin (glucophage) oral agent

Answer 1

Biguanide

Question 2

Biguanide Generic name

Answer 2

Metformin (glucophage)

Question 3

Biguanide Mechanism

Answer 3

Decrease hepatic glc output
Decrease insulin resistance
Increase Peripheral glucose utilization

Question 4

Biguanide site of action

Answer 4

liver

Question 5

Biguanide Hypoglycemia?

Answer 5

No

Question 6

Glipizide (glucotrol) oral agent

Answer 6

Sulphonylureas

Question 7

Glyburide (Micronase) oral agent

Answer 7

Sulphonylureas

Question 8

Glimepepiride (Amaryl) oral agent

Answer 8

Sulphonylureas

Question 9

Sulphonylureas Mechanism

Answer 9

Directly increase insulin secretion

Bind to SUR1-stimulates beta cells by closure of K+ ATP channels

Question 10

Sulphonylureas Site of action

Answer 10

Pancreas

Question 11

Sulphonylureas Hypoglycemia?

Answer 11

yes

Question 12

Sitagliptin (Januvia) oral agent

Answer 12

DPP-4 inhibitors

Question 13

DPP4-inhibitor generic name

Answer 13

Sitagliptin (Januvia)

Question 14

DPP-4 inhibitors Mechanism

Answer 14

Decrease gastric emptying

Increase GLP-1

Question 15

DPP-4 inhibitors site of action

Answer 15

Stomach

Question 16

DPP-4 inhibitors hypoglycemia?

Answer 16

Possible

Question 17

Pioglitazone (Actos)

Rosigltazone (Avandia) oral agent

Answer 17

Thiazolidinedoines

Question 18

Thiazolidinedoines generic name

Answer 18

Pioglitazone (Actos)

Rosigltazone (Avandia)

Question 19

Thiazolidinedoines mechanism

Answer 19

Increase peripheral insulin sensitivity (primary)
Increase adipogenesis
Decrease hepatic glucose prouction

Question 20

Thiazolidinedoines sit of action

Answer 20

Liver, muscle, adipose

Question 21

Thiazolidinedoines hypoglycemia?

Answer 21

NO

Question 22

Canaglilozin (Invokana)

Empagliflozin (Jardiance) Oral agent

Answer 22

SGLT-2 inhibitors

Question 23

SGLT-2 inhibitors generic name

Answer 23

Canaglilozin (Invokana)

Empagliflozin (Jardiance)

Question 24

SGLT-2 inhibitors Mechanism

Answer 24

Block activity of sodium glucose transport proteins in the kidney
Decrease glucose reuptake
Increase glucose seretion in urine

Question 25

SGLT-2 inhibitors site of action

Answer 25

Kidney

Question 26

SGLT-2 inhibitors Hypoglycemia

Answer 26

No

Question 27

Acarbose (Precose) | Miglitol (Glyset) oral agent

Answer 27

a-glucosidase inhibitors

Question 28

a-glucosidase inhibitors generic name

Answer 28

Acarbose (Precose) | Miglitol (Glyset)

Question 29

a-glucosidase mechanism

Answer 29

Slow digestion of CHO in small inestine | Decrease peak BG by delaying abd

Question 30

a-glucosidase site of action

Answer 30

GI-tract

Question 31

a-glucosidase hypoglycemia?

Answer 31

NO

Question 32

Pramlintide (symlin) oral agent

Answer 32

Amylin analogue (injection)

Question 33

Amylin analogue generic name

Answer 33

Pramlintide (symlin)

Question 34

Amylin analogue mechanism

Answer 34

Decrease glucagon secretion Slow gastric emptying Increase satiety

Question 35

Amylin analogue site of action

Answer 35

GI and pancreas

Question 36

Amylin analogue hypoglycemia?

Answer 36

Yes

Question 37

Exenatide (byetta) oral agent

Answer 37

GLP-1 receprot agonist (injection)

Question 38

GLP-1 receptor generic name

Answer 38

Exenatide (Byetta)

Question 39

GLP-1 receptor Mechanism

Answer 39

Increase insulin secretion Slow glucose absorption Decrease postprandial glucagon secretion Increase satiety

Question 40

GLP-1 receptor site of action

Answer 40

Pancrease | GI ract

Question 41

GLP-1 receptor hypoglycemia

Answer 41

Possible