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FS HN 461 > DM2 Medications > Flashcards

DM2 Medications Flashcards

1
Q

Metformin (glucophage) oral agent

A

Biguanide

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2
Q

Biguanide Generic name

A

Metformin (glucophage)

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3
Q

Biguanide Mechanism

A

Decrease hepatic glc output
Decrease insulin resistance
Increase Peripheral glucose utilization

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4
Q

Biguanide site of action

A

liver

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5
Q

Biguanide Hypoglycemia?

A

No

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6
Q

Glipizide (glucotrol) oral agent

A

Sulphonylureas

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7
Q

Glyburide (Micronase) oral agent

A

Sulphonylureas

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8
Q

Glimepepiride (Amaryl) oral agent

A

Sulphonylureas

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9
Q

Sulphonylureas Mechanism

A

Directly increase insulin secretion

Bind to SUR1-stimulates beta cells by closure of K+ ATP channels

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10
Q

Sulphonylureas Site of action

A

Pancreas

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11
Q

Sulphonylureas Hypoglycemia?

A

yes

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12
Q

Sitagliptin (Januvia) oral agent

A

DPP-4 inhibitors

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13
Q

DPP4-inhibitor generic name

A

Sitagliptin (Januvia)

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14
Q

DPP-4 inhibitors Mechanism

A

Decrease gastric emptying

Increase GLP-1

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15
Q

DPP-4 inhibitors site of action

A

Stomach

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16
Q

DPP-4 inhibitors hypoglycemia?

A

Possible

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17
Q

Pioglitazone (Actos)

Rosigltazone (Avandia) oral agent

A

Thiazolidinedoines

18
Q

Thiazolidinedoines generic name

A

Pioglitazone (Actos)

Rosigltazone (Avandia)

19
Q

Thiazolidinedoines mechanism

A

Increase peripheral insulin sensitivity (primary)
Increase adipogenesis
Decrease hepatic glucose prouction

20
Q

Thiazolidinedoines sit of action

A

Liver, muscle, adipose

21
Q

Thiazolidinedoines hypoglycemia?

A

NO

22
Q

Canaglilozin (Invokana)

Empagliflozin (Jardiance) Oral agent

A

SGLT-2 inhibitors

23
Q

SGLT-2 inhibitors generic name

A

Canaglilozin (Invokana)

Empagliflozin (Jardiance)

24
Q

SGLT-2 inhibitors Mechanism

A

Block activity of sodium glucose transport proteins in the kidney
Decrease glucose reuptake
Increase glucose seretion in urine

25
Q

SGLT-2 inhibitors site of action

A

Kidney

26
Q

SGLT-2 inhibitors Hypoglycemia

A

No

27
Q

Acarbose (Precose)

Miglitol (Glyset) oral agent

A

a-glucosidase inhibitors

28
Q

a-glucosidase inhibitors generic name

A

Acarbose (Precose)

Miglitol (Glyset)

29
Q

a-glucosidase mechanism

A

Slow digestion of CHO in small inestine

Decrease peak BG by delaying abd

30
Q

a-glucosidase site of action

A

GI-tract

31
Q

a-glucosidase hypoglycemia?

A

NO

32
Q

Pramlintide (symlin) oral agent

A

Amylin analogue (injection)

33
Q

Amylin analogue generic name

A

Pramlintide (symlin)

34
Q

Amylin analogue mechanism

A

Decrease glucagon secretion
Slow gastric emptying
Increase satiety

35
Q

Amylin analogue site of action

A

GI and pancreas

36
Q

Amylin analogue hypoglycemia?

A

Yes

37
Q

Exenatide (byetta) oral agent

A

GLP-1 receprot agonist (injection)

38
Q

GLP-1 receptor generic name

A

Exenatide (Byetta)

39
Q

GLP-1 receptor Mechanism

A

Increase insulin secretion
Slow glucose absorption
Decrease postprandial glucagon secretion
Increase satiety

40
Q

GLP-1 receptor site of action

A

Pancrease

GI ract

41
Q

GLP-1 receptor hypoglycemia

A

Possible

FS HN 461 (8 decks)

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