Diuritcs Flashcards
Diuretics are classified to three groups
High effect diuretics like ______
Medium effect like _______
Mild/ low effect like 1_____2_____3______
Loop diuretics
Thiazide
Potassium sparing, osmotic and carbonic anhydrase
Which is wrong about osmotic diuretics :
A it should exert osmotic effect
B it should be pharmacologically active
C it should be freely filtered at glomerulus
D it should not be reabsorbed
B
Following drugs are inter except
A mannitol
B urea
C isosorbide
D glycerol
E furosemide
E
All true about taking osmotic diuretic except
A hypernatremia due to less natriuritc effect than h2o diurisis
B leads to expansion in extra cellular fluid volume
C increase in renal blood flow and GFR
D reaches loop do Henle and DCT
D PCT
Following are true about Mannitol except
A rapidly distributed and
B may cause osmotic diarrhea if givien parenterally
C used in cerebral edema
D treatment of glaucoma
B orally
Side effects of mannitol except
A hyponatremia
B heart failure and polmonary edema in impaired renal function patients
C cns symptoms
D dehydration
A hypernatremia
The only diuretic that cause hypernatremia is
A acetazolamide
B furosemide
C mannitol
D thiazide
C
Carbonic anhydrase inhibitors that are sulfonamide derivatives, except
A acetazolamide
B Dorsalamdie
C Torsemide
D brinzolamide
C
which is true about CAI
A act on thick as sending loop of henle
B non competitive reversible inhibitors
C decrease hco3 reabsorption
D b and c
D
Alkalinization of urine in cases of aspirin toxicity or dissolving Uris acid crystal can be done by
A forusamide
B acetazolamide
C indapamibe
D amiloride
B
All the following are uses of acetazolamide, CAIs except
A mountain sickness
B glaucoma, severe edema
C epilepsy
D alkalinization of urine
E Metabolic acidosis 
E
Phosphate and ca stones( renal stones ) due to Alkalinization of urine is a side effect of what drugs
A loop diuretics
B CAIs
C K sparing
D thiazide
B ( acetazolamide
Side effects of acetazolamide CAIs except
A hyperchloremic acidosis
B hypokalemia
C hepatic insufficiency
D CNS stimulation
D cns inhibition
Liver cirrhosis and acute renal failure are contraindications in which drug
A mannitol
B acetazolamide
C furosemide
D thiazide
B
Sulfonamide loop diuretics except
A furosemide
B bumetanide
C torsemide
D ethacrynic acid
D non sulfonamide loop diuretic
loop diuretics act by the following mechanisms except
A decrease reabsorption of magnesium and calcium
B increase prostaglandin release and renal blood flow increases 
C increase systemic venous capacity and left ventricular pressure by PG
D increase excretion of sodium chloride and potassium chloride
C decrease lt v pressure
Indications of loop diuretics include all except
A any type of edema
B when GFR <10ml/ min
C treatment of hypokalemia
D hypertension
C hyper
Antihypertensive drug act only by its diuretic effect and has NO direct VD effect is
A mannitol
B furosemide
C indapamide
D ethacrynic acid
E both b and d
E
Ototoxicity is a side effect of
A Triamterene
B furosemide
C Metolazone
D acetazolamide
B ( loop diuretics)
Which is untrue bout the drug interaction related to loop diuretics
A w/ digitalis -> arrhythmia
B w/ NSAID -> decrease their response ( decrease PG synthesis)
C w/ amphotericin B, cephalosporins -> Nephritis
D w/ aminoglycosides ( gentamicin ) -> GIT disturbance
D Ototoxicity
Git is side effect of loop diuretics
Thiazide like drugs are,except
A indapamide
B hydrochlorothiazide
C brinzolamide
D metolazone
C
Which is untrue bout thiazide diuretics
A enhance ca reabsorption
B indapamide has direct VD effect
C cause hyponatremia
D cause hypocalcemia
D
Which drug has a great direct VD effect
A indapamide
B Metolazone
C spironolactone
D furosemide
A
The only diuretic that can cause Hypercalcemia
A furosemide
B mannitol
C Metolazone
D spironolactone
C thiazide diuretics
Also indapamide and hydrochlorothiazide
