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Pharma > Diuritcs > Flashcards

Diuritcs Flashcards

1
Q

Diuretics are classified to three groups
High effect diuretics like ______
Medium effect like _______
Mild/ low effect like 1_____2_____3______

A

Loop diuretics
Thiazide
Potassium sparing, osmotic and carbonic anhydrase

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2
Q

Which is wrong about osmotic diuretics :
A it should exert osmotic effect
B it should be pharmacologically active
C it should be freely filtered at glomerulus
D it should not be reabsorbed

A

B

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3
Q

Following drugs are inter except
A mannitol
B urea
C isosorbide
D glycerol
E furosemide

A

E

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4
Q

All true about taking osmotic diuretic except
A hypernatremia due to less natriuritc effect than h2o diurisis
B leads to expansion in extra cellular fluid volume
C increase in renal blood flow and GFR
D reaches loop do Henle and DCT

A

D PCT

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5
Q

Following are true about Mannitol except
A rapidly distributed and
B may cause osmotic diarrhea if givien parenterally
C used in cerebral edema
D treatment of glaucoma

A

B orally

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6
Q

Side effects of mannitol except
A hyponatremia
B heart failure and polmonary edema in impaired renal function patients
C cns symptoms
D dehydration

A

A hypernatremia

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7
Q

The only diuretic that cause hypernatremia is
A acetazolamide
B furosemide
C mannitol
D thiazide

A

C

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8
Q

Carbonic anhydrase inhibitors that are sulfonamide derivatives, except
A acetazolamide
B Dorsalamdie
C Torsemide
D brinzolamide

A

C

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9
Q

which is true about CAI
A act on thick as sending loop of henle
B non competitive reversible inhibitors
C decrease hco3 reabsorption
D b and c

A

D

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10
Q

Alkalinization of urine in cases of aspirin toxicity or dissolving Uris acid crystal can be done by
A forusamide
B acetazolamide
C indapamibe
D amiloride

A

B

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11
Q

All the following are uses of acetazolamide, CAIs except
A mountain sickness
B glaucoma, severe edema
C epilepsy
D alkalinization of urine
E Metabolic acidosis 

A

E

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12
Q

Phosphate and ca stones( renal stones ) due to Alkalinization of urine is a side effect of what drugs
A loop diuretics
B CAIs
C K sparing
D thiazide

A

B ( acetazolamide

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13
Q

Side effects of acetazolamide CAIs except
A hyperchloremic acidosis
B hypokalemia
C hepatic insufficiency
D CNS stimulation

A

D cns inhibition

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14
Q

Liver cirrhosis and acute renal failure are contraindications in which drug
A mannitol
B acetazolamide
C furosemide
D thiazide

A

B

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15
Q

Sulfonamide loop diuretics except
A furosemide
B bumetanide
C torsemide
D ethacrynic acid

A

D non sulfonamide loop diuretic

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16
Q

loop diuretics act by the following mechanisms except
A decrease reabsorption of magnesium and calcium
B increase prostaglandin release and renal blood flow increases 
C increase systemic venous capacity and left ventricular pressure by PG
D increase excretion of sodium chloride and potassium chloride

A

C decrease lt v pressure

17
Q

Indications of loop diuretics include all except
A any type of edema
B when GFR <10ml/ min
C treatment of hypokalemia
D hypertension

A

C hyper

18
Q

Antihypertensive drug act only by its diuretic effect and has NO direct VD effect is
A mannitol
B furosemide
C indapamide
D ethacrynic acid
E both b and d

A

E

19
Q

Ototoxicity is a side effect of
A Triamterene
B furosemide
C Metolazone
D acetazolamide

A

B ( loop diuretics)

20
Q

Which is untrue bout the drug interaction related to loop diuretics
A w/ digitalis -> arrhythmia
B w/ NSAID -> decrease their response ( decrease PG synthesis)
C w/ amphotericin B, cephalosporins -> Nephritis
D w/ aminoglycosides ( gentamicin ) -> GIT disturbance

A

D Ototoxicity
Git is side effect of loop diuretics

21
Q

Thiazide like drugs are,except
A indapamide
B hydrochlorothiazide
C brinzolamide
D metolazone

A

C

22
Q

Which is untrue bout thiazide diuretics
A enhance ca reabsorption
B indapamide has direct VD effect
C cause hyponatremia
D cause hypocalcemia

A

D

23
Q

Which drug has a great direct VD effect
A indapamide
B Metolazone
C spironolactone
D furosemide

A

A

24
Q

The only diuretic that can cause Hypercalcemia
A furosemide
B mannitol
C Metolazone
D spironolactone

A

C thiazide diuretics
Also indapamide and hydrochlorothiazide

25
Q

Uses of thiazide diuretics include all except
A Nephrogenic DI
B CHF, mild edem
C treatment of hypercalcemia, prevent ca stones
D diabetic or gout patients
E both c and d

A

E
C hypercalciuria

26
Q

Side effects of thiazide except
A hyperlipidemia
B hyperuricemia
C hyperglycemia
D hypercalcemia
E non of the above

A

E

27
Q

Anti androgenic effect is done by :
A thiazide
B loop diuretics
C k sparing
D CAIs

A

C ( spironolactone)

28
Q

The only diuretic that cause hyperkalemia is ?

A

Spironolactone k sparing

29
Q

The only diuretic that cause hypernatremia is

A

Mannitol osmotic

30
Q

The only diuretic casing hypercalcemia

A

Thiazide

31
Q

Drug used to treat hyperaldosteronism

A

Spironolactone

32
Q

Toxicity of spironolactone increased by all except
A renal disease
B NSAID, B blockers ( decrease renin )
C ACEI, Ang receptor inhibitors
D all of the above

A

D

33
Q

Following drugs can cause renal stones except
A acetazolamide
B triametrene
C dorsolamide
D Metolazone

A

D thiazides actually help preventing renal stones

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