Diuretics: Ch. 2-3: HCTZ, chlorthaladone Flashcards
Thiazides work by _______ by blocking the ______ in the distal convoluted tubule.
- inhibiting NaCl reabsorption
- blocking the NaCl cotransporter
About ____% of filtered sodium is absorbed at the distal convoluted tubule.
10%
The distal convoluted tubule is ____ to water.
impermeable
Calcium reabsorption is mediated by ____.
PTH
What acid-base disturbance can thiazide diuretics cause?
metabolic alkalosis
What effect do thiazides have on calcium?
increased reabsorption
Why can thiazide diuretics cause gout?
dehydration –> hyperuricemia and crystallization
Because thiazide diuretics cause hypocalciuria, they can be used to prevent ______.
calcium kidney stones
Thiazides can cause what increases in lab values?
- hypercalcemia
- hyperlipidemia
- hyperglycemia
- hyperuricemia
- high lithium levels
How do thiazides work?
increased excretion of NaCl
Thiazide diuretics are potassium ______.
wasting
What is the difference btw HCTZ and chlorthaladone?
chlorthaladone has a longer duration of action (longer half life)
Name a urate lowering drug.
allopurinol
Where in the nephron do thiazide diuretics work?
the distal convoluted tubule
What drug class do thiazides belong to?
sulfa drugs
