3.1: Ca++ Channel Blockers Flashcards
Which Ca++ channel blockers should be chosen for tx of stable angina?
- dihydropyrinidines
- ex: amilodipine, felodipine
Name the nondihydropyrinidines.
- verapamil
- diltiazem
What receptor do Ca++ channel blockers inhibit? Where?
- voltage gated L-type Ca++ channel blockers
- on cardiac and smooth muscle
How do Ca++ channel blockers treat stable angina?
- dilate coronary arteries
- reduce afterload
- enhance development of coronary collaterals
What do the dihydropyrinidines end in?
- -dipine
- ex: nifedipine, amlodipine, nicardipine
Which Ca++ channel blockers should be used to treat berry aneurism/subarachnoid hemorrhage?
- dihydropyridine
- *** nimodipine
Name a tx for Raynauds.
- dihydropyridines
- ex: nefedipine, amylodipine
____ is a safe Ca++ channel blocker in pregnancy.
Nifedipine
What is a contraindication for nifedipine? Why?
- unstable angina or MI
- reflex tachycardia
What kind of Ca++ channel blocker is diltiazem?
a nondihydropyrinidine
What are the ADRs for Ca++ channel blockers? In which class are they more common?
- lightheadedness
- flushing
- HA
- peripheral edema
- reflex tachycardia
- ***more common in dihydropyridines, nifedipine
What are the major ADRs for verapamil?
- constipation
- gingival hypertrophy
Which Ca++ blocker is the strongest on the heart?
verapamil
IV _______ Ca++ channel blockers, such as ____ and ____, can treat hypertensive emergencies.
- dihydropyridine
- ex: clevidipine, nicardipine
What kind of Ca++ channel blocker is verapamil?
a nondihydropyrinidine
