Diuretics

Question 1

Furosemide

Answer 1

Loop

Question 2

Bumetanide

Answer 2

Loop

Question 3

Ethacrynic Acid

Answer 3

Loop

Question 4

Torsemide

Answer 4

Loop

Question 5

Loop MOA

Answer 5

Inhibit Na/K/Cl active CO-transporter in thick ascending,

Excretes Ca,Mg,H,K,Cl,Na,

Pulmonary vasodilation

Question 6

Chlorothiazide

Answer 6

Thiazide

Question 7

Hydrochlorothiazide

Answer 7

Thiazide

Question 8

Chlorthiodone

Answer 8

Thiazide

Question 9

Indapamide

Answer 9

Thiazide

Question 10

Metolazone

Answer 10

Thiazide

Question 11

Thiazide Uses

Answer 11

Ca retention to prevent kidney stones, ect,

D. Insipidus.

Question 12

Glycerin

Answer 12

Osmotic

Question 13

Isosorbide

Answer 13

Osmotic

Question 14

Mannitol

Answer 14

Osmotic

Question 15

Osmotic MOA

Answer 15

inert increase of osmolarity in tubule,

All electrolytes increase excretion.

Question 16

Spironolactone

Answer 16

Potassium Sparing

Question 17

Eplerenone

Answer 17

Potassium Sparing

Question 18

Triamterine

Answer 18

Potassium Sparing

Question 19

Amiloride

Answer 19

Potassium Sparing

Question 20

Potassium Sparing (Spiron) MOA

Answer 20

Inhibits aldosterone reducing AIP production,

= Less Na channel production = Less Na/K trade

Question 21

Spironolactone and Aldosterone

Answer 21

Very effective in reducing the systemic effects of aldosterone pathologies

Question 22

Acetazolamide

Answer 22

Carbonic anhydrase inhibitor

Question 23

Dorzolamide

Answer 23

Carbonic anhydrase inhibitor

Question 24

Carbonic anhydrase inhibitor (Uses)

Answer 24

Mountain sickness,

corrects alkalosis caused by Loop and Thiazides,

short term adjunct therapy,

glaucoma.

Question 25

Loop (Uses)

Answer 25

Asthma,

Hypercalcemia, Hyperkalemia

Question 26

Loop (Kinetics)

Answer 26

Protein bound

Question 27

Loop (Long term phenomenon)

Answer 27

Braking Phenomenon - less effective doses by keeping more Na with each dose.

Question 28

Thiazide (Kinetics)

Answer 28

Protein bound,

Proximal tube,

Weak C. Anhydrase Inhibitor.

Question 29

Thiazide (Disadvantage)

Answer 29

Same as Loop:

Cause: HypoK, hypoH2O, HyperCa, HyperUrea, HyperGlyc.

Question 30

Osmotic (Disadvantage)

Answer 30

Cause:

HypoNa, HA, N/V.

Question 31

Osmotic (Uses)

Answer 31

Brain edema,

Glaucoma,

ARF,

Eliminate toxins.

Question 32

Potassium Sparing (Amilo/Triam) MOA

Answer 32

Direct inhibition of Na channel = Less Na transport = Less Na/K trade

Question 33

Potassium Sparing (Kinetics)

Answer 33

Collecting duct/Distal tubule

Question 34

Diuretic of choice for Hepatic cirrhosis

Answer 34

Spironolactone