DIURETICS Flashcards

1
Q

Example of Osmotic diuretic

A

Mannitol

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2
Q

Site of action of osmotic diuretics

A

Proximal tubule

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3
Q

Mechanism of osmotic diuretic

A

Osmotically draws water out of the ICF

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4
Q

Use of osmotic diuretic

A

Used in acute settings as it is fast acting

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5
Q

Site of action of Carbonic anhydrase inhibitors

A

Proximal tubule

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6
Q

Mechanism of carbonic anhydrase inhibitor

A

Inhibits CA

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7
Q

Use of carbonic anhydrase

A

Glaucoma

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8
Q

Example of loop diuretic

A

Furosemide

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9
Q

Site of action of loop diuretics

A

Thick ascending limb

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10
Q

Mechanism of loop diuretics

A

blocks Na/K/2Cl symporter

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11
Q

Use of loop diuretics

A

most effective

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12
Q

Example of thiazide diuretic

A

hydrochlorothiazide

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13
Q

Site of action of thiazide diuretics

A

Distal tubule

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14
Q

Mechanism of thiazide diuretics

A

inhibits Na/cl symporter

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15
Q

Use of thiazide diuretics

A

K sparring

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16
Q

Example of ENaC inhibitor

A

Amiloride

17
Q

Site of action of ENaC inhib.

A

collecting duct

18
Q

Mechanism of ENaC inhib.

A

inhibits ENaC channel

19
Q

Use of ENaC inhib.

A

K sparring

20
Q

Example of mineralocortical receptor antagonist

A

spirinolactone

21
Q

Site of action of mineralocortical receptor antagonist

A

Collecting duct

22
Q

Mechanism of mineralocortical receptor antagonist

A

aldosterone antagonist, decreases the amount of ENaC and Na/KATPase

23
Q

Use of mineralocortical receptor antagonist

A

K sparring

24
Q

Example of a methylxanthine

A

Caffeine

25
Q

mechanism of methylxanthine

A

increase GFR via pre-renal mechanism