Diuretic Sites of Action

Question 1

Carbonic Anhydrase Inhibitors

Answer 1

Proximal tubule

Question 2

Osmotic Diuretics

Answer 2

Renal proximal tubule and descending limb of loop of Henle

Question 3

Na+-K+-2Cl- symport inhibitors (loop diuretics)

Answer 3

Thick ascending limb of the loop of Henle

Question 4

Na+-Cl- symport inhibitors (Thiazide and thiazide-like diuretics)

Answer 4

Primarily on the distal convoluted tubule and proximal tubule secondary

Question 5

Renal epithelial Na+ channel inhibitors (potassium-sparing diuretics)

Answer 5

Late distal tubule and collecting duct

Question 6

Mineralocorticoid receptor antagonists (MRA) (aldosterone antagonists, potassium-sparing diuretics)

Answer 6

Late distal tubule and collecting duct

Question 7

Vasopressin antagonists

Answer 7

V2 receptor on the basolateral membrane of the principal cell of the collecting duct