Anticoagulant Drugs Hockerman

Question 1

Which clotting factors are not made in the liver?

Answer 1

-von Willebrand factor
-Thromboplastin (tissue factor)
-Factor 8 is also produced in the endothelium as well as the liver

Question 2

How is the extrinsic pathway triggered?

Answer 2

Through tissue injury

Question 3

How is the intrinsic pathway triggered

Answer 3

When collagen is exposed on the wall of the blood vessel

Question 4

What makes the intrinsic pathway different from the extrinsic pathway?

Answer 4

-The intrinsic pathway has all of its components already in the blood while the extrinsic pathway relies on the release of tissue thromboplastin to initiate the pathway
-The extrinsic pathway is much more rapid taking around 15 seconds for a clot to start forming