DIT XIII: Psych

Question 1

Criteria for Dx of major depressive episode

Answer 1

5 symptoms + depressed mood/anhedonia for 2 weeks
“SIG E CAPS”: Sleep (hyper/hyposomnia), Interest, Guilt, Energy, Concentration, Appetite, Psychomotor retardation/agitation, Suicidal ideation

Question 2

Features of atypical depression

Answer 2

Hypersomnia, hyperphagia, mood reactivity, hypersensitivity to rejection

Question 3

Rx for atypical depression

Answer 3

SSRIs

Question 4

Risk factors for suicide

Answer 4

“SAD PERSONS”: Sex (m), Age (teens and elderly), Depression, Prev attempts, EtOH, Rational thinking (decr), Sickness, Organized plan, No social support, Stated future intent

Question 5

What is dysthymia

Answer 5

milder form of depression for at least 2 yrs

Question 6

MOA of SSRIs

Answer 6

blocks reuptake of 5-HT

Question 7

MOA of SNRIs

Answer 7

blocks reuptake of 5-HT and NE

Question 8

MOA of TCAs

Answer 8

blocks reuptake of NE and 5-HT

Question 9

MOA of MAOIs

Answer 9

inhibits MAO (which breaks down catecholamines, incl NE)

Question 10

What is the MAOI washout period?

Answer 10

wait 2 wks after stopping MAOI before taking anything else

Question 11

Name the class: fluoxetine, sertraline, paroxetine, citalopram, fluvoxamine

Answer 11

SSRI

Question 12

Name the class: nortriptyline, imipramine, amitriptyline, desipramine, nortriptyline, clomipramine, doxepin

Answer 12

TCA

Question 13

Name the class: selegiline, phenelzine, trancylcypromine

Answer 13

MAOI

Question 14

Name the class: venlafaxine, duloxetine, milnacipram

Answer 14

SNRI

Question 15

Name the class: mirtazapine, trazodone

Answer 15

Tetracyclic antidepressant

Question 16

Which antidepressant has side effect of priapism

Answer 16

trazodone

Question 17

Which antidepressant lowers the seizure threshold

Answer 17

bupropion, TCAs

Question 18

Which antidepressant works well with SSRIs and increases REM sleep

Answer 18

trazodone

Question 19

Which antidepressant is an appetite stimulant that is likely to result in wt gain?

Answer 19

mirtazapine

Question 20

Antidepressant that can be used for smoking cessation

Answer 20

buproprion

Question 21

Antidepressant that can be used for bedwetting in children

Answer 21

imipramine

Question 22

Symptoms of TCA overdose

Answer 22

Coma, Convulsions, Cardiotoxicity (“Tri-Cs”)

+ resp depression, confusion

Question 23

Symptoms of serotonin syndrome

Answer 23

Mental status changes, autonomic instability (CVS collapse, hyperthermia), neuromusc abn (musc rigidity)

Question 24

What happens when you ingest tyramine while on MAOIs?

Answer 24

HTN crisis, hemorrhagic stroke, cardiac arrhythmias

Tyramine increases NE if no MAO enzymes