Disseminated intravascular coagulation Flashcards
1
Q
what is DIC
A
dysregulated coagulation and fibrinolysis
-> widespread clotting with resultant bleeding
one critical mediator of DIC= TF
2
Q
causes of DIC
A
sepsis
trauma
obstetric complications (amniotic fluid embolism or haemolysis, HELLP)
malignancy
3
Q
diagnosis of DIC
A
low platelets
low fibrinogen
high PT and APTT
high fibrinogen degradation products
schistocytes due to microangiopathic haemolytic anaemia
