Disorders of Pregnancy in the Mare Flashcards
Started on slide 12
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When does most fetal loss occur?
Before day 50
General diagnostic approach to abortion
- Make sure it is an actual abortion
- History (e.g. pregnancy diagnosis, vaccinations, movement)
- Laboratory findings (fetus size, length, defects; umbilical cord; placenta; histopathology, serology, virology, bacteriology)
What is the major non-infectious cause of abortion?
- Twinning
What should you think of as the cause of abortion if the fetus looks abnormal?
- Congenital defect
What is abortion?
- Premature expulsion from the uterus of the products of conception
Approximately what % are infections of all causes of abortions?
- Approximately one third to half of all causes
What % of abortions remain undiagnosed?
- 5-20%
Which viral diseases cause abortion?
- EHV and EVA
What are the most common isolates for bacterial placentitis( and which is MOST common)?
- Streptococcus spp (zooepidemicus)**
- Staphylococcus spp
- E. coli*
- Klebsiella
- Enterobacter
- Pseudomonas*
Samples to be sent in for equine abortion
- Fetus
- Serum and vaginal swab from the dam
- Placenta
Pathophysiology of bacterial placentitis?
- Bacteria infiltrate and colonize the space between microcotyledons and microvilli of the uterus
Ascending placentitis causes
- Look at spreadsheet
What is the cervical star?
- It’s the part of the placenta right against the cervix
- You can see it become discolored with ascending placentitis
What should you think if you hear premature udder development and mucopurulent vaginal discharge?
- Think ascendent placentitis
Features of placentitis in the fetus?
- Persistent fetal tachycardia
Features of placentitis in the uteroplacental unit?
- Thickening of the uterine wall (>13 mm)
- Increased CUPT (>17.5 mm)
- Pockets of hyperechoic fluids (pus)
- Areas of placental separation
Endocrinology signs with placentitis (progesterone, estrogen)
- Increased total progesterone concentration
- Decreased total estrogens
Acute phase protein changes in placentitis
- Elevation of acute phase proteins (serum amyloid A and haptoglobin)
Outcome of ascendent placentitis
- Often foals born healthy but small
- Pregnancy may be a little shorter
- Increased risk for perinatal asphyxia syndrome but similar survival rate and discharge time compared to controls
- Treatment reduces risk of neonatal encephalitis, neonatal nephropathy, and neonatal enteropathy
Funisitis***
- umbilical cord inflammation
Clinical signs in the mare of leptospirosis
- VARIABLE AND NOT ALWAYS PRESENT
- Fever
- Hematuria
- Acute renal failure
- Uveitis may develop weeks after abortion
- Mid to late term abortion (usually last 3 months)
Types of foals that can be born if dam has leptospirosis?
- Stillborn or weak (important cause of FPTI)
Pathologic findings of leptospirosis in the placenta
- Placentitis not involving the cervical star
- Heavy, edematous, hemorrhagic
- Occasionally covered with a brown mucoid material on the chorionic surface
- Calcification
- Funisitis in some cases
Pathologic findings of leptospirosis in the fetus
- mild to moderate icterus
- Liver enlargement, hepatitis
- Tubulonephrosis and interstitial nephritis
Diagnosis of leptospirosis with agglutinating antibody titers in the mare - what value is diagnostic?
- > 1:6400 often >12,800
Other diagnostics besides high antibody titers for leptospirosis?
- Fetal and placental lesions
- Fetal antibodies
- Isolation from placenta or renal tubules
- IHC of the placenta, umbilical cord, or fetal kidney and liver
- PCR
Prevention of leptospirosis techniques?
- Isolate aborting mare for 14-16 weeks
- Urine FAT testing for shedding
- Possible treatment of shedders or animals at high risk (e.g. those in a flood plain)
- Limit exposure to stagnant water
- Control reservoir animals
- Vaccine available
When in gestation does abortion secondary to nocardioform placentitis occur?
- Late term abortion
- Premature birth
- Weak foals
Clinical signs in the mare of nocardioform placentitis?
- May show premature mammary gland development and/or galactorrhea
Placenta in nocardioform placentitis
- Chronic
- Severe, exudative, mucopurulent, and necrotizing placentitis at the junction of the placental body and horns
Fetus pathology in nocardioform placentitis
- Severely underdeveloped
What is the most commonly isolated actinomycete from nocardioform placentitis?***
Crossiella equi
Which type of EHV is most common in abortions secondary to EHV?
- EHV1
- EHV4 possible but rare
Time period of abortion in EHV?
- most between 8-10 months
Can vaccinated mares still have an abortion secondary to EHV?
- Yes
- Thought to be reactivation of latent infection