Disorders of Myelination Flashcards
1
Q
MS
A
Symptoms are separated by time and space eye issues WOMEN - 3rd 4th dec Relapsing--Remitting course Demyelinating plaques periventricular Oligoclona bands - IgG in CSF
Tx - high dose steroids
2
Q
Metachromatic Leukodystrophy
A
Varied neuro symptom
Arylsulfatase A deficiency
3
Q
Progressive Multifocal Leukoncephalopathy
A
JC Virus
Immunocompromised - AIDS
4
Q
Central Pontine Myelinolysis
A
Pseudobulbar palsy Spastic Quadriparesis Locked in syndrome - fatal focal demyelination - corticospinal and corticobulbar tracts malnourished, liver disease, alchys CAUSED BY OVERTRAETMENT OF HYPO Na+
5
Q
Guillain-Barre
A
Weakness starts at lower limbs and ascends
resp failure
absent reflexes
hx of resp or GI illness 2 weeks prior
Albuminocytologic dissociation – elevated CSF protein but normal cel count
6
Q
Charcot Marie Tooth Disease
A
weakness in distal limbs
Abnormal proprioception
7
Q
Acute Disseminated Post infectious Encephalomyelitis
A
symptoms similar to MS
constituional symtpoms
mental status changes
prepubertal children
