Basal Ganglia Disease

Question 1

Cogwheel rigidity
Pill rolling tremor
shuffling gait
loss of pigmented neurons fro substantia nigra
lewy bodies

Answer 1

Parkinsons

Question 2

chorea - random rapid movmetns
20-40s
degeneration of GABA
chromo 4

Answer 2

Huntington Disease

Question 3

parkinsonian + chorea
fatty chang - hep - cirrhosis
Kayser Fleischer ring

Answer 3

Wilson Disease

Question 4

Hemorrhagic destrction of contralateral subthaaamic nuclei

Answer 4

Hemiballism

Question 5

uncontrolled vocal tics

Answer 5

Tourettes

Question 6

what is the pharm goal in treating parkinsons

Answer 6

increase DA or decrease ACh activity in striatum

to fix the DA ACh imbalance

Question 7

dopamine precursor that can cross the BBB

converted to DA

Answer 7

L-DOPA

Question 8

DOPA decarboxylase inhibitor

Answer 8

prevents L-DOPA from being converted to dopamine in the periphery
only lets it be conveted int he brain

Question 9

this is now considered the first line of therapy for PD

also used for restless leg syndrome

Answer 9

DA agnosists

Question 10

MAO B Inhibitor

Answer 10

inhibits it so it can’t metabolizes dopanine