DISEASES RELATED TO LIVER FUNCTION

Question 1

● Comes from the word “Jaune” meaning yellow

Answer 1

JAUNDICE

Question 2

Characterized by the yellow discoloration of the skin,
mucous membrane, and sclera, most often because of
bilirubin

Answer 2

JAUNDICE

Question 3

→ Refers to to serum or plasma with yellow discoloration due to
elevated bilirubin

Answer 3

Icterus

Question 4

Excessive amount of bilirubin is presented to the liver for
metabolism

Answer 4

A. PREHEPATIC JAUNDICE

Question 5

▪ ↑ breakdown of RBCs

Answer 5

Hemolysis

Question 6

▪ ↑ breakdown of RBCs

Answer 6

→ Hemolytic anemia

Question 7

breakdown of RBCs because of the parasite Plasmodium
spp

Answer 7

Malaria

Question 8

→ Biliary obstruction diseases

Answer 8

▪ Gallstones, tumor

Question 9

Benign autosomal recessive hereditary disorder
● Genetic mutation of UGT1A1

Answer 9

Gilbert Syndrome

Question 10

More serious than Gilbert syndrome
● Characterized by deficiency of the enzyme UDPGT

Answer 10

Crigler-Najjar Syndrome

Question 11

Autosomal recessive disease which presents shortly after birth
with an increase of conjugated bilirubin without elevation of liver
enzymes (ALT, AST)

Answer 11

Dublin-Johnson Syndrome

Question 12

Deficiency in canalicular multidrug resistance/ multispecific
organic anionic transporter protein (MDR2/cMOAT

Answer 12

Dublin-Johnson Syndrome

Question 13

● Liver granules are not pigmented(liver biopsy)

Answer 13

Rotor’s Syndrome

Question 14

● Unknown etiology; Good prognosis

Answer 14

Rotor’s Syndrome

Question 15

● Same symptoms with Dubin-Johnson Syndrome

Answer 15

Rotor’s syndrome

Question 16

→ Neuronal degeneration

Answer 16

● Kernicterus

Question 17

● Bilirubin-conjugation inhibition
→ ↑B1
● Aka. Transient Familial Neonatal Hyperbilirubinemia TFNH
● Circulating inhibitor of bilirubin conjugation

Answer 17

Lucey-Driscoll Syndrome