Diseases of the hypothalamus

Question 1

Diseases of the hypothalamus

Answer 1

Tumors (astrocytoma, glioma, germinoma, craniopharyngeoma, large pituitary tumor, lymphoma)
Haemorrhages
Developmental abnormalities (arachnoideal cyst, holoprosencephaly)
Granulomatous infection (histiocytosis, sarcoidosis, TBC)
Inflammation (meningitis, encephalitis)
Trauma
Irradiation
Hereditary diseases

Question 2

Endocrine consequences of hypothalamic disease

Answer 2

Deficiency of trophormones: CRH, TRH, GHRH, GnRH, which will lead to growth failure, hypopituitarism, disorders of sexual development
Deficiency of posterior pituitary hormones

Question 3

Non-endocine consequences of hypothalamic disease

Answer 3

Feeding disorders, disorders of fluid intake, disorders of thermoregulation, somnolent, coma, lightheadedness, mood liability