Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CV Pharmacology- Parker > Direct vasodilators > Flashcards

Direct vasodilators Flashcards

1
Q

List the direct vasodilators

A

Monday Night Football in HD: Minoxidil, Nitroprusside, Fenoldopam, Hydralazine, Diazoxide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Minoxidil’s mech of action and effect

A

Opens K+ channels which relaxes vascular smooth muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Does Minoxidil vasodilate arterioles, veins, or both?

A

Arterioles ONLY!!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Important side effects of Minoxidil?

A

reflex tachycardia, and POWERFUL renin release!! Like holy shit, thats a lot of renin!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Nitroprusside is a prodrug that is metabolized into?

A

NO- nitrous oxide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Does nitroprusside vasodilate arterioles, veins, or both?

A

BOTH!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Mech of action of nitroprusside

A

increases intracellular cGMP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

side effects of nitroprusside?

A
  1. Reflex tachycardia
  2. Hypotension
  3. NO is metabolized to cyanide which is toxic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Clinical use for nitroprusside?

A

HTN emergency!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Fenoldopam’s mech of action?

A

Dopamine receptor agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Fenoldopam half life?

A

10 minutes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Clinical uses of fenoldopam?

A

IV drip for HTN emergency!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Side effects of fenoldopam?

A

reflex tachycardia, increased intraocular pressure (contraindicated in glaucoma)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Hydralazine side effects

A
  1. Palpitations
  2. Reflex tachycardia
  3. Autoimmune reactions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which direct vasodilator would you use for HTN emergency from pregnancy (eclampsia)

A

Hydralazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which direct vasodilator would you give with BBB antihypertensives and a diuretic because you are concerned about reflex sympathetic responses?

A

Hydralazine

17
Q

Diazoxide mech of action?

A

Opens K+ channels (just like Minoxidil)

18
Q

Clinical use for Diazoxide?

A

HTN emergency!!

19
Q

side effects of Diazoxide?

A
  1. Reflex tachycardia
  2. Hypotension
  3. Hyperglycemia (cuz diazoxide inhibits insulin release)

CV Pharmacology- Parker (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions