ACE inhibitors Flashcards

1
Q

ACE inhibitors end in? List them

A

“pril” CLER… Captopril, Lisinopril, Enalapril, Ramipril

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2
Q

Mech of action of ACE inhibitors?

A

Inhibit conversion of angiotensin I to angiotensin II and degrade bradykinin (a potent bronchodilator)

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3
Q

ACE inhibitors increase renal blood flow (RBF) without changing GFR.. this results in?

A

decrease filtration fraction

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4
Q

Major use of ACE inhibitors?

A

Treat HTN in CHF patients

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5
Q

Which ACE inhibitor is renoprotective in diabetes?

A

Captopril; it increases synthesis of prostaglandins in vascular and renal endothelium

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6
Q

This ACEI is a prodrug given IV for HTN emergencies

A

Enalapril

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7
Q

This ACEI is a lysine derivative of enalapralit and is renoprotective

A

Lisinopril

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8
Q

This ACEI has a long half life and is given daily

A

Ramipril

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9
Q

Side effects of ACEI

A

hypotension, dry cough, hyperkalemia, angioedema, fetotoxicity

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