ACE inhibitors Flashcards
ACE inhibitors end in? List them
“pril” CLER… Captopril, Lisinopril, Enalapril, Ramipril
Mech of action of ACE inhibitors?
Inhibit conversion of angiotensin I to angiotensin II and degrade bradykinin (a potent bronchodilator)
ACE inhibitors increase renal blood flow (RBF) without changing GFR.. this results in?
decrease filtration fraction
Major use of ACE inhibitors?
Treat HTN in CHF patients
Which ACE inhibitor is renoprotective in diabetes?
Captopril; it increases synthesis of prostaglandins in vascular and renal endothelium
This ACEI is a prodrug given IV for HTN emergencies
Enalapril
This ACEI is a lysine derivative of enalapralit and is renoprotective
Lisinopril
This ACEI has a long half life and is given daily
Ramipril
Side effects of ACEI
hypotension, dry cough, hyperkalemia, angioedema, fetotoxicity