Differential diagnosis Flashcards
(blank)is defined as the reduction of the total circulating red cell mass below normal limits.
anemia
Anemia is diagnosed base on what?
hematocrit, hemoglobin
hemoglobin and mcv depend on what?
age, sex, ethnicity
Newborns have higher what?
mcv
Limit for differentiatin anemia from normal is set at (blank)
2 sd
Hb is higher in males cuz of what?
testosterone anddrogens
anemias are classified based on MCV,RDW, HB, and blank
reticulocyte count
what does hypochromic mean?
reduced hb based on color
what are microcytic hypochromic anemias caused by?
disorders of hb synthesis, i.e thalassemias or iron deficiency
marocytic anemias are often associated with abnormalities that impair (blank) of erythroid precursors in the bone marrows?
maturation (retic count important)
nomochromic and normocytic anemias may be associated with anemia in (blank) disease
chronic
If the degree of reticulocytosis is adequate to replace the loss of red blood cells, the anemia is termed “blank.”
If not able to compensate then it will blank
compensated.
worsen
anemias may be based on what three types of defects of the red blood cell?
intrinsic, environmental, extrinisic
Production disordres cause the production of RBCs to be either blank or blank
hypoplastic, or aplastic
What can create normocytic RBC but not enough of them>?
drugs, newly replaced bone marrow, and infections
How can you get microcytic or macrocytic cells?
iron deficiency, b12 deficiency, folate deficiency, Hb chain disorders
What are the extrinsic ways you can have a destruction disorder?
RBC marked with antigen and spleen pulls it off making it shriveled OR rbc can travel through a messed up organ making it shriveled.
What are the intrinisc ways RBC can be messed up?
abnormal membrane or H chains or enzyme disorder
What are the steps in definitive diagnosis?
H & P, Lab tests, Define anemia i.e. blood loss, production or destruction,
What are some tests that can determine anemia?
CBC, Iron levels, FOlate and B12 levels, coombs, hemoglobim, retic count, bilirubi and blood and urine tests.
Anemia may be either relative ….
(due to increased plasma volume with a normal red blood cell mass)
Anemia may be absolute…
due to decreased red blood cell mass
