DIC-syndrome Flashcards
1
Q
definition
A
- a pathological condition occurring secondary to an underlying disease and characterized by inappropriate activation of the coagulation and fibrinolytic activation of the coagulation and fibrinolytic systems
- there is consumption of fibrin, clotting factors ( esp factor V, VIII, prothrombin ) and platlets, resulting in continued bleeding + futher depletion of factors
2
Q
etiology
A
- intrauterine fetal death
- IU fetal death and retention of dead fetus for > 3 weeks 🡪 leakage of thrombop??? + thromboplastin-like substances into maternal circulation from degenerating placenta + as well as plasminogen activates from fetus + placenta - placental abruption – in this case:
i) hemorrhage + retroplacental clot formation result in depletion of fibrinogen, platlets, coagulation factors
ii) damaged placenta + uterus release tissue thromboplastine + plasminogen activator into general circulation - AF embolism – complication of artificial rupture of membrane, CS, external vergoon, causes
i) at release of tissue thrombopastine
ii) increase coagulation due to pro-coaggulant activates of AF - PE, eclampsia – chronic co-aggulation abN 🡪 thrombocytopenia + increase fibrin degradation products ( due to platlet adherence to damaged endothelium )
- saline / septic abortion
- release of tissue thromboplastin from placenta / necrotic tissue
- septic abortion 🡪 also release of bacterial endotoxin ( phospholipids ) which is a pro-coaggulant
i) Hypercoagulation – consumption of platlets and coagulant factor
ii) Hypocoagulation – start bleeing
3
Q
stages
A
Compensation
1. co-aggulation stage – stage during which there is release of thromboplastin + activation of clotting shunt formation
Subcompensation
2. fibrinogen depletion – during this stage, there is fibrinogen depletion even if thromboplastin are not present due to exhaustion of clotting system
- fibrinolysis – secondary to activation of fibrinolysis system by product of fibrin breakdownn 71
