Diazepam (Valium)

Question 1

Diazepam Class:

Answer 1

Benzodiazepine, sedative-hypnotic, anticonvulsant.

Question 2

Diazepam Mechanism of Action:

Answer 2

• Potentates effects of inhibitory neurotransmitters.
• Raises seizure threshold.
• Induces amnesia and sedation.

Question 3

Diazepam Indications:

Answer 3

Acute anxiety states
Acute alcohol withdrawal
Muscle relaxant
Seizure activity
Agitation
Analgesia for medical procedures
Delirium tremens

Question 4

Diazepam Adult Dose:

Answer 4

• Seizure activity: 5-10 mg IV q 10-15 minutes prn (5 mg over 5 min.)(maximum dose = 30 mgs.)
• Rectal diazepam: 0.5 mg/kg via 2” rectal catheter and flush with 2-3 ml air after administration.
• Sedation for cardioversion: 5- 15 mg IV over 5-10 minutes prior to cardioversion.

Question 5

Diazepam Pediatric Dose:

Answer 5

• Seizure activity: 0.2-0.3 mg/kg/dose IV every 15-30 minutes (no faster than 3 mg over 5 minutes) (max. = 10 mg).
• Rectal diazepam: 0.5 mg/kg via 2” rectal catheter and flush with 2-3 ml air after administration.
• Sedation for cardioversion: 5- 15 mg IV over 5-10 minutes prior to cardioversion.