Diarrhoea + Vomiting Flashcards

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1
Q

What questions do you want to ask in a history of d+v?

A
  • Duration, frequency/number, volume and colour of vomitus/stools
  • Current oral intake and usual feeding pattern
  • Passage of urine - number of wet nappies, if nappies are as heavy as before and how long ago did the child have a wet nappy
  • Hx of fever and other red flag symptoms
  • Recent contact with someone with d+v, ingestion of contaminated food or water and recent travel abroad
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2
Q

What are the physical features of dehydration in an infant?

A
  • Sunken anterior fontanelle (usually closes at 18-24 months)
  • Decreased consciousness
  • Eyes sunken and tearless
  • Dry mucous membranes
  • Tachycardia (+ hypotension) - peripheral vasoconstriction
  • Tachypnoea
  • Decreased CRT and skin turgor
  • Sudden weight loss
  • Oliguria
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3
Q

What are common causes of gastroenteritis in young children?

A
  • Rotavirus: most common, most children in the UK have this by age 5 and develop immunity. More common in infants and young children, than in teenagers
  • Adenovirus: more common in infants and young children than in teenagers
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4
Q

What are the causes of blood in stool with d+v?

A
  • Intussusception: invagination of proximal bowl into distal segment commonly involving invagination of ileum into caecum through the ileocecal valve
  • Rotavirus: presenting symptoms are fever, vomiting and diarrhoea with/without blood in stool
  • E.coli: associated with diarrhoea with blood in stool and haemolytic uraemic syndrome. Occurs in clusters after ingestion of contaminated food.
  • Campylobacter
  • Shigella
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5
Q

What is the presentation of intussusception?

A
  • Peak presentation between 3 months to 2 years of age with history of paroxysmal, severe colicky pain when the child draws his/her legs up, pallor during episodes of pain followed by recovery from the painful episodes and lethargy
  • The child may refuse to feed, have vomiting and pass characteristic red currant jelly stool containing blood and mucus (late sign due to mucosal breakdown)
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6
Q

What are red flag features associated with vomiting?

A
  • Blood
  • Bile in vomitus
  • Projectile vomiting
  • Abdominal tenderness/distension
  • Blood in stool
  • Bulging fontanelle
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7
Q

What does vomiting indicate in infancy and childhood?

A
  • Vomiting is a common symptom in infancy and childhood. It is usually benign and is caused by feeding issues, gastroesophageal reflux and gastroenteritis.
  • Vomiting can be a symptom of potentially serious underlying problem in infants and young children if persistent or associated with fever when it may be associated with infections such as UTI or meningitis.
  • Proximal intestinal obstruction can cause bilious vomiting with abdominal distension.
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8
Q

What can cause:

  • bile stained vomit
  • projectile vomiting >2 months
  • vomiting with paroxysmal cough
  • bulging fontanelle/fits
A
  • Bile stained vomit: intestinal obstruction
  • Projectile vomiting >2 months: pyloric stenosis
  • Vomiting with paroxysmal cough: whooping cough
  • Bulging fontanelle/fits: increased ICP due to meningitis/hydrocephalus
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9
Q

What causes haematemesis?

A
  • Oesophagitis
  • Gastric ulcer
  • Oral or nasal bleeding and vomiting up swallowed blood
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10
Q

What causes abdominal distension/tenderness?

A
  • Intestinal obstruction
  • Strangulated inguinal hernia
  • Surgical abdomen
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11
Q

What causes blood in the stool?

A
  • Gastroenteritis - salmonella or campylobacter
  • Intussusception
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12
Q

What causes severe dehydration and shock?

A
  • Severe gastroenteritis
  • Systemic infection - UTI
  • Meningitis
  • DKA
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13
Q

What causes faltering growth?

A
  • GORD
  • Coeliac disease
  • Chronic GI conditions
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14
Q

How is the clinical diagnosis of gastroenteritis made?

A

It is based on a sudden change in stool consistency to loose or watery stools +/or sudden onset of vomiting.

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15
Q

What do urine dipstick results mean?

A
  • If leucocyte esterase and nitrite are negative - diagnosis of UTI unlikely
  • If leucocyte esterase and nitrites positive - suggests UTI
  • Negative leucocyte esterase and positive nitrites - preliminary diagnosis of UTI can be made, can start abx treatment whilst awaiting urine culture result
  • Trace of blood and protein can present in child with intercurrent illness
  • Positive ketones - indicates starvation
  • Raised glucose and ketones - DKA
  • Increased blood and protein - nephritis
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16
Q

What are the common food poisoning organisms?

A
  • Campylobacter are the most common cause of food poisoning in the UK and are found in raw or undercooked meat, particularly poultry
  • Salmonella are often present in raw or undercooked meat, raw eggs, milk etc
  • Listeria may be found in chilled ready to eat foods - pre-packed sandwiches, cooked sliced meats pate and brie cheese etc - listeria infection in pregnant women can cause miscarriage and infection of newborn
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17
Q

How is food poisoning spread?

A

Contamination can occur through touching infected animals, their faeces, or coming into contact with people who have the illness - especially if correct handwashing practices are not followed after using the toilet or before handling food. Suspected food poisoning is a notifiable condition and it is statutory duty of registered medical practitioners to notify PHE of any suspected infectious diseases.

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18
Q

How do you manage mildly dehydrated children?

A
  • Fluid challenge with oral rehydration solution (ORS) - frequently and in small amounts
  • Consider giving 5ml/kg of ORS after each large watery stool in children who are at increased risk of dehydration - low birth weight, age <1yr, had >2 vomiting episodes and >5 diarrhoea episodes in previous 24hrs
  • Continue breastfeeding or other milk feeds. Discourage use of fruit juices and carbonated drinks which increase the risk of dehydration
  • Consider giving ORS via NG tube if unable to drink or persistent vomiting. Monitor rehydration: oral intake, passage of urine, no. and volume of vomits and loose stools, signs of dehydration
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19
Q

How would you counsel parents with children who have gastroenteritis?

A
  • Tends to last 5-7 days, in most children it stops in 2 weeks
  • Continue intake of usual fluids (breast milk or formula) and give 5ml/kg of ORS after passage of each loose stool
  • Wash hands with soap and warm running water after changing nappies and before preparing, serving and eating food
  • Avoid nursery/school for at least 48 hours after last episode of d or v
  • Call GP if child becomes unwell, appears pale/mottled, starts vomiting again (vomiting shouldn’t last >3 days), has decreased urine output/wet nappies, irritable/lethargic and has cold extremities
20
Q

What is oral rehydration solution?

A

ORS helps with the absorption of sodium and this also helps water be absorbed to rehydrate the body. Composition of low osmolarity ORS:

  • Sodium chloride 2.6g/l
  • Glucose anhydrous 13.5g/l
  • Potassium chloride 1.5g/l
  • Trisodium citrate dihydrate 2.9g/l
21
Q

When should solid food be started and breast/formula feeds stopped?

A
  • Solid food can be introduced at 6 months of age; some parents introduce solids earlier as they feel the infant is hungry. Initially the baby may be offered rice, pureed fruit and vegetables. Use of eggs, wheat and fish should be avoided <6 months of age.
  • Breast or formula feeds should be continued until 12 months of age when whole pasteurised cow’s milk can be introduced. Unmodified cow’s milk has higher amount of protein, electrolytes and inadequate iron and vitamins so is therefore not suitable in infancy.
  • Mature breast milk provides 62kcal/100ml and cow’s milk formulae 60-65kcal/100ml.
22
Q

What is the protein and calorie requirement of babies?

A
  • Calories and protein requirement - 0-6 months of age 115kcal/kg and 2.2gm/kg/day, 6-12 months 96kcal/kg and 2gm/kg/day respectively
  • Breast milk is ideal nutrition for infants in first 4-6 months of age. It reduces the risk of gastroenteritis and is life saving in developing countries.
23
Q

What happens to feeding in gastroenteritis?

A
  • Breast feeding or formula feeds can be continued during gastroenteritis if the child is tolerating oral fluids and should be introduced by 24hrs if stopped due to persistent vomiting
  • Infants are more vulnerable to poor nutrition due to inadequate stores of fat and protein, extra nutritional demands for growth and frequent intercurrent illness which cause reduction or oral intake and increased demands.
24
Q

What is the epidemiology of gastroenteritis?

A
  • Gastroenteritis is a major cause of mortality in developing countries. In the UK 10% of children <5yrs of age present to health services with gastroenteritis and it is a cause of significant morbidity in younger children.
  • Rotavirus causes gastroenteritis in 60% of children <2yrs of age particularly in winter and in early spring. Gastroenteritis due to bacterial infection is less common in the UK; campylobacter jejuni is the commonest bacterial infection
25
Q

What viruses cause gastroenteritis?

A
  • Rotavirus
  • Enteric adenovirus 40+41
  • Calcivirus (including norovirus)
  • Astrovirus
26
Q

What bacterias cause gastroenteritis?

A
  • Campylobacter jejuni
  • C.diff
  • E.coli
  • Salmonella
  • Shigella
  • Vibrio cholerae
27
Q

What parasites cause gastroenteritis?

A
  • Giardia lamblia
  • Cryptosporidium
28
Q

What is the mechanism of infectious diarrhoea?

A
  1. Secretory (watery stool): decreased absorption, increased secretion and electrolyte transport, causes are cholera, E.coli, C.diff, cryptosporidium (in HIV)
  2. Mucosal invasion (blood and increased WBCs): inflammation, decreased mucosal surface area +/or colonic reabsorption and increased motility, causes are rotavirus, campylobacter, salmonella, shigella, Yersinia
29
Q

What situations makes you think of gastroenteritis?

A

Can occur after contact with someone with acute diarrhoea +/or vomiting, exposure to contaminated water or food and recent travel abroad.

30
Q

What are red flags associated with d+v?

A
  • Fever: temp >38 degrees or higher in children <3 months and >39 degrees or higher in children aged >/= 3 months
  • Tachypnoea
  • Altered conscious level
  • Neck stiffness
  • Bulging fontanelle in infants
  • Non-blanching rash
  • Blood +/or mucus in stool
  • Bilious vomit
  • Severe or localised abdo pain
  • Abdominal distension or rebound tenderness
31
Q

How is mild dehydration categorised?

A
  • Body weight (% loss): <4
  • General appearance: thirsty, alert
  • Skin turgor: normal
  • Tears: present
  • Mucous membranes: moist
  • BP: normal
  • Urine flow: normal
  • Pulse: normal
  • Eyes: normal
  • Anterior fontanelle: normal
  • Fluid deficit: up to 40ml/kg
32
Q

How is moderate dehydration categorised?

A
  • Body weight (% loss): 4-6
  • General appearance: thirsty, restless, lethargic
  • Skin turgor: reduced
  • Tears: absent
  • Mucous membranes: dry
  • BP: normal or low
  • Urine flow: decreased and concentrated
  • Pulse: raised
  • Eyes: sunken
  • Anterior fontanelle: sunken
  • Fluid deficit: 40-60ml/kg
33
Q

How is severe dehydration categorised?

A
  • Body weight (% loss): >7
  • General appearance: drowsy, cold, sweaty
  • Skin turgor: reduced
  • Tears: absent
  • Mucous membranes: very dry
  • BP: low, maybe unrecordable
  • Urine flow: marked oliguria
  • Pulse: rapid, weak, maybe impalpable
  • Eyes: grossly sunken
  • Anterior fontanelle: very sunken
  • Fluid deficit: >70ml/kg
34
Q

Who is the risk of dehydration increased in?

A
  • Children <1yr, particularly under 6 months of age
  • Low birth weight infants
  • If >5 loose stools and 2 episodes of vomiting in previous 24hrs
  • Not offered or able to tolerate supplementary fluids before presentation
  • Malnourished children
35
Q

What are the causes of dehydration?

A
  • Isonatremic: loss of sodium and water are proportional and the plasma sodium remains within normal range
  • Hyponatremic: intake of large quantity of water/hypotonic fluids, greater net loss of sodium than water, fall in serum sodium, resulting in a shift of water from extracellular to intracellular compartment, causing brain oedema and marked extracellular dehydration and shock.
  • Hypernatraemic: water loss > sodium loss so increase in plasma sodium concentration. This can happen when there is low sodium diarrhoea or high insensible water. There is a shift of water from intracellular to extracellular compartment and therefore less signs of dehydration.
36
Q

What are the features of hypernatraemia dehydration?

A
  • Jittery movements
  • Increased muscle tone
  • Hyperreflexia
  • Convulsions
  • Drowsiness or coma
37
Q

What investigations would you do for someone who is dehydrated?

A
  • Stool microscopy and culture is indicated if: recent travel abroad, diarrhoea isn’t improving by day 7, suspected septicaemia, blood +/or mucus in stool, immunocompromised child
  • Blood culture - if starting abx
  • U+Es and glucose if dehydrated/starting IV fluids
38
Q

What are the indications for IV fluids?

A
  • Shock
  • Red flag symptoms or signs
  • Persistent vomiting
  • Hypoglycaemia
39
Q

What is the management for shock?

A
  • Fluid bolus 20ml/kg - 0.9% NaCl, rapid IV infusion
  • Second bolus of 20ml/kg - 0.9% NaCl - rapid IV infusion (if shock persists)
  • Once symptoms resolve start rehydration via IV fluids
40
Q

What are different fluids used for?

A
  • Isotonic fluids (0.9% NaCl, 4.5% albumin and Hartmann’s solution) - only to be used for resuscitation i.e. to give a bolus of fluid
  • 0.9% NaCl and 5% dextrose is an isotonic fluid - can be used for maintenance and correction of ongoing fluid losses
41
Q

How do you calculate maintenance IV fluids?

A
  • First 0-10kg: give 100ml/kg (A)
  • Second 10-20kg: give 50ml/kg (B)
  • Any kg >20kg: give 20ml/kg (C)
  • Total fluid volume for 24hrs: A+B+C=D
  • Maintenance fluid (ml/hr) = D/24hrs
42
Q

What do you need to measure before starting IV fluids?

A
  • Measure weight and U+Es before starting IV fluids then at least every 24hrs if U+Es are normal.
  • Measure blood glucose when starting IV fluids and at least every 24hrs or more frequently if there is hypoglycaemia risk.
43
Q

How do you calculate the volume of ORS to give?

A
  • Mild dehydration 50ml/kg over 4hrs
  • Moderate dehydration 100ml/kg over 4hrs
  • Ongoing losses (stool) 5-10ml/kg
  • Reduce fluid intake when patient appears clinically rehydrated
  • Breast or formula feeding can be continued and should not be delayed for >24hrs
44
Q

What are antibiotics given to treat?

A
  • Campylobacter: erythromycin shortens duration of illness and shedding of bacteria
  • C. diff: metronidazole or vancomycin
  • Nontyphoid salmonella, shigella, vibrio cholerae, giardia, Yersinia, cryptosporidium
45
Q

How can acute appendicitis present?

A
  • Right leg limping gait
  • Mesenteric adenitis would be a key differential especially if there was hx of a sore throat
46
Q

What are the investigations and management of intussusception?

A
  • USS is diagnostic
  • Repeated examination of the abdomen may be needed as the bowel can telescope in and out again
  • Treatment, in a specialist centre can be attempted reduction by air enema or surgery