diagnostics for renal Flashcards
what are the 6 functions of the kidney
- eliminate toxic substances
- regulate body water and solute conc
- regulate acid-base balance
- excrete nitrogenous waste (urea and crew)
- regulate electrolyte comp
- endocrine (EPO, renin, metabolites of VitD)
what are the 6 functions of the kidney
- eliminate toxic substances
- regulate body water and solute conc
- regulate acid-base balance
- excrete nitrogenous waste (urea and crew)
- regulate electrolyte comp
- endocrine (EPO, renin, metabolites of VitD)
what is GFR
rate fluid moves from plasma to glomerular filtrate
how is GFR measured
the rate a substance is cleared from plasma - crea, inulin
what affects GFR
renal perfusion and renal plasma flow
define renal failure
decreased renal function due to decreasing no of functional nephrons
define azotaemia
increase in non-protein nitrogenous compounds - usually urea ± crea
define uraemia
clinical signs and biochem abnormalities ass w loss of functional nephrons
signs of uraemia
d+, v+, anorexia, ulcerative stomatitis, GI haemorrhage (bruxism in ruminants)
what is USG
measure of kidneys ability to conc urine
what range = isosthenuric
1.008-1.012
what range = hyposthenuric
what range = conc
cat = 1.035 dog = 1.030
what is haematuria
intact blood in urine
what causes haematuria
trauma, cystitis, renal bleeding, GT bleeding
what is haemoglobinuria
contents of RBC in urine
causes of haemoglubinuria
haemolytic anaemia, decreased HCT
what is myoglobinuria
muscle oxygen carrying protein in urine
causes of myoglobinuria
severe muscle damage
causes of bilirubin in urine
overspill into urine when levels increase in blood due to haemolytic anaemia, liver dz, gall bladder or bile duct obstruction (higher threshold in cats)
what is GFR
rate fluid moves from plasma to glomerular filtrate
how is GFR measured
the rate a substance is cleared from plasma - crea, inulin
what affects GFR
renal perfusion and renal plasma flow
define renal failure
decreased renal function due to decreasing no of functional nephrons