Diagnosing Bleeding Disorders Flashcards
1
Q
What does APTT stand for? What pathway does it describe?
A
Activated Partial Thromboplastin Time - intrinsic pathway
2
Q
What does PTT stand for? What pathway does it describe?
A
Prothrombin Time - extrinsic pathway
3
Q
Deficiencies in what factors will prolong the PPT time?
A
F7 (and F10)
4
Q
Deficiencies in what factors will prolong the APPT time?
A
F12, F11, F9, F8 (and F10)
5
Q
Why does F10 affect both APPT and PPT?
A
F10 is in the common pathway
6
Q
How can you tell if there is a clotting factor missing?
A
Mixing normal plasma with plasma of someone with disease - if clotting becomes normal it tells you there is clotting factor missing
