Diabetic Foot Flashcards
haemostasis
vasoconstriction: stops the bleeding
platelet response: forms blood clot and preliminary extra cellular matrix
stages of wound healing
- inflammatory phase
- reconstruction/proliferation phase
- maturation phase
inflammatory phase
0-3 days
arrival of neutrophils: protect would against bacterial invasion
arrival of macrophages: clear wound of debris
reconstruction/proliferation phase
2-24 days
macrophages begin to stimulate fibroblasts to produce collagen
new capillary development is seen in granulation tissue called angiogenesis
epithelial cells migrate over the granulated wound bed
maturation phase
24 days - 1 year
remodelling - increase the tensile strength
collagen is replaced in a more organised manner
the epithelial layer thickens
decrease in vascularity and scar size
chronic wounds are defined by
four straight weeks of non healing
failure to proceed through an orderly and timely process to produce anatomic and functional integrity
intrinsic factors limiting would healing
- age
- disease eg. peripheral arterial disease, diabetes mellitus
- stress
extrinsic factors limiting wound healing
malnutrition
obesity
smoking
drugs
chemotherapy
some drugs that may limit wound healing
anti-inflammatory
anti-coagulants
corticosteroids
immunosuppressive
local factors affecting healing
wound management practices
hydration of the wound
pressure, shear and friction
foreign bodies
wound infection
necrotic tissue will usually require
debridement
sloughy tissue
granulating tissue
hypergrnaulating tissue
epitheliating tissue