diabetic drugs Flashcards

1
Q

short acting

A

Regular insulin (Humulin R/Novolin R)

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2
Q
  • SQ
  • Seen given IV
  • 0.5 to 1 hr
A

Regular insulin (Humulin R/Novolin R)

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3
Q

rapid acting insulin

A
  • Lisproe
  • Aspart
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4
Q

Intermediate acting insulin

A

Insulin isophane suspension (NPH)

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5
Q
  • Action time – 15 minutes
  • Take with or right before meal to prevent hypoglycemia
  • SQ
A

rapid acting insulin

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6
Q
  • Cloudy insulin
  • Mixed with regular
A

Intermediate acting insulin

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7
Q

What two insulins are often mixed together?

A

RN – Regular first then NPH
short and intermediate

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8
Q

what is short and rapid acting based on?

A

Short acting or rapid acting given based on FSBS

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9
Q

what is Biguanides?

A

an oral diabetic drug class used in 2 and the drug is metformin

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10
Q
  • Decreases glucose production in the liver/intestinal absorption of glucose
  • Improves insulin receptor sensitivity
  • A.E. GI and metallic taste
  • Long term effects: b12 and b9 deficiency
  • DON’T USE: Iodine containing contrast, if pt is predisposed hypoxia or lactic acidosis
A

metformin

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11
Q

drugs in Sulfonylureas class?

A

Glipizide
Glyburide

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12
Q
  • Bind to receptor sites in pancreas to stimulate the release of insulin
  • decrease glucagon
  • best in early diabetes 2
  • STOP if/when insulin is needed
  • only pts with working beta cells in the pancreas- not for type 1 diabetics
  • NO: NPO, alcohol, elderly, allergy to sulfonamide, hypoglycemia pts
  • A.E. hypoglycemia, weight gain, GI and rash
A

Sulfonylureas

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13
Q

what drugs are too similar to be used together?

A

Sulfonylureas and Glinides (Meglitinides)

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14
Q

what are the drugs in the drug class Glinides (Meglitinides)?

A

Repaglinide

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15
Q
  • Shorter duration than sulfonylureas
  • Given with each meal
  • A.E. hypoglycemia, weight gain
A

Glinides (Meglitinides); Repaglinide

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16
Q

what are the drugs in the drug class Thiazolidinediones (Glitazones)?

A

Pioglitazone

17
Q
  • Decreases insulin resistance
  • Several weeks to work
  • CAN be used with insulin
  • DON’T USE severe CHF, liver or kidney
  • A.E. edema, weight gain, decrease bone density lead to fractures esp. if high osteoporosis
A

Thiazolidinediones (Glitazones); Pioglitazone

18
Q

what drugs are in the Alpha-Glucosidase inhibitors class?

A

Acarbose

19
Q
  • not used often
  • inhibits enzymes in small intestines
  • delays glucose absorption
  • take with food
  • decreases glucose spike
  • GI effects e.g. flatulence
  • No weight gain or hypoglycemia
  • Decreases digoxin (lanoxin) and propranolol (Inderal) function
A

Alpha-Glucosidase inhibitors;Acarbose

20
Q

Dipeptidyl peptidase IV inhibitors (Gliptins)

A

Sitagliptin

21
Q
  • delays the breakdown of incretin hormones (released in day and after meal)
  • reduces fasting and postprandial glucose concentrations
  • sitagliptin + sulfonylurea = hypoglycemia
A

Dipeptidyl peptidase IV inhibitors (Gliptins); Sitagliptin