Diabetes T2 Drugs Flashcards
What’s the 1st line thx for DMT2
Lifestyle modifications
What drug class does metformin belong to?
Biguanide
What is the MOA of metformin?
Increases insulin sensitivity and decreases hepatic gluconeogenesis
What are the side effects of metformin
Lactic acidosis*
GI upset
What is the MOA of sulfonylureas
Stimulate beta pancreatic cells to produce insulin by binding to ATPk channels on beta cells
What is the side effects of sulfonylureas
Weight gain
Hypoglycaemia*
Hyponatremia
GI upset
What do sulfonylureas drugs end in
Glimepride
Glicazide
What is the MOA of thiazolidinediones
Promote adipogenesis and ffa uptake
What are the side effects of thiazolidinediones
Weight gain
Fluid retention
Name a thiazolidinediones drug
Pioglitazone
What is the MOA do DPP-4 inhibitors
Increase incretin levels which inhibit glucagon secretion
What are the side effects of DPP-4 Inhibitors
Generally well tolerated but increase risk of pancreatitis
What to DPP-4 inhibitors drugs name end in
Gliptins
What is the MOA of SGLT2- inhibitors
Inhibit reabsorption of glucose in the kidneys
What are the side effects of SGLT2-Inhibitors
Weight loss, UTI
What do SGLT2-Inhibitors drug name end in
Gliflozins
What is the MOA of GLP-1 agonists
Incretin mimetic thus inhibit glucagon secretion (s/c)
Side effects of GLP-1 agonists
Weight loss, N+V, Pancreatitis
What do glp-1 agonist drugs end in
-tides
