Diabetes T2 Drugs

Question 1

What’s the 1st line thx for DMT2

Answer 1

Lifestyle modifications

Question 2

What drug class does metformin belong to?

Answer 2

Biguanide

Question 3

What is the MOA of metformin?

Answer 3

Increases insulin sensitivity and decreases hepatic gluconeogenesis

Question 4

What are the side effects of metformin

Answer 4

Lactic acidosis*

GI upset

Question 5

What is the MOA of sulfonylureas

Answer 5

Stimulate beta pancreatic cells to produce insulin by binding to ATPk channels on beta cells

Question 6

What is the side effects of sulfonylureas

Answer 6

Weight gain
Hypoglycaemia*
Hyponatremia
GI upset

Question 7

What do sulfonylureas drugs end in

Answer 7

Glimepride

Glicazide

Question 8

What is the MOA of thiazolidinediones

Answer 8

Promote adipogenesis and ffa uptake

Question 9

What are the side effects of thiazolidinediones

Answer 9

Weight gain

Fluid retention

Question 10

Name a thiazolidinediones drug

Answer 10

Pioglitazone

Question 11

What is the MOA do DPP-4 inhibitors

Answer 11

Increase incretin levels which inhibit glucagon secretion

Question 12

What are the side effects of DPP-4 Inhibitors

Answer 12

Generally well tolerated but increase risk of pancreatitis

Question 13

What to DPP-4 inhibitors drugs name end in

Answer 13

Gliptins

Question 14

What is the MOA of SGLT2- inhibitors

Answer 14

Inhibit reabsorption of glucose in the kidneys

Question 15

What are the side effects of SGLT2-Inhibitors

Answer 15

Weight loss, UTI

Question 16

What do SGLT2-Inhibitors drug name end in

Answer 16

Gliflozins

Question 17

What is the MOA of GLP-1 agonists

Answer 17

Incretin mimetic thus inhibit glucagon secretion (s/c)

Question 18

Side effects of GLP-1 agonists

Answer 18

Weight loss, N+V, Pancreatitis

Question 19

What do glp-1 agonist drugs end in

Answer 19

-tides