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Pharm Unit 6 > Diabetes Part 2 > Flashcards

Diabetes Part 2 Flashcards

1
Q

biguanides

A

metformin (Glucophage®)

first line agent for tx of T2DM

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2
Q

MOA of metformin

A

inhibit hepatic gluconeogenesis

increases insulin receptor sensitivity

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3
Q

side effects of metformin

A

lactic acidosis, GI side effects, take with food

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4
Q

MOA of sulfonylureas

A

stimulate beta cells to release insulin

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5
Q

side effects of sulfonylureas

A

hypoglycemia, weight gain, GI upset

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6
Q

what do all sulfonylureas start with

A

gly or gli

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7
Q

MOA of meglitinides

A

stimulate beta cells to release insulin

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8
Q

side effects of meglitinides

A

hypoglycemia, weight gain, take 15 mins prior to meal

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9
Q

what do all meglitinides end in

A

glinide

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10
Q

MOA of thiazolidinediones

A

increase insulin sensitivity, decrease hepatic gluconeogensis

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11
Q

side effects of thiazolidinediones

A

edema, weight gain, hepatotoxicity, bone fractures, monitor LFTs

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12
Q

what do all thiazolidinediones end in

A

glitazone

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13
Q

MOA of alpha-glucosidase inhibitors

A

delays digestion of carbs

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14
Q

side effects of alpha-glucosidase inhibitors

A

bloating, flatulence, take with first bite of each meal, do not take with Beano®

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15
Q

MOA of SGLT2 inhibitors

A

inhibit sodium-glucose cotransporter, excrete glucose in urine

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16
Q

side effects of SGLT2 inhibitors

A

UTI, yeast infection, dehydration, hypotension, hyperkalemia

17
Q

what do all SGLT2 inhibitors end in

A

aglifozin

18
Q

MOA of DPP-IV inhibitors

A

inhibit breakdown in incretin hormones

19
Q

side effects of DPP-IV inhibitors

A

nasopharyngitis, rash, pancreatitis, arthralgia

20
Q

what do all DPP-IV inhibitors end in

A

agliptin

21
Q

MOA of GLP-1 agonists

A

increase insulin secretion, delay stomach emptying and glucagon secretion

22
Q

side effects of GLP-1 agonists

A

N/V/D, hypoglycemia, weight loss, pancreatitis

23
Q

what do all GLP-1 agonists end in

A

tide

24
Q

normal post-prandial level

A

<200 mg/dL

25
Q

normal HbA1C

A

<6%

26
Q

level of HbA1C to diagnose diabetes

A

6.5%

Pharm Unit 6 (8 decks)

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