Diabetes Insipidus Flashcards
1
Q
What is central diabetes insipidus?
A
the pituitary in the CNS is not producing enough ADH
2
Q
What is nephrogenic diabetes insipidus?
A
the receptors in the kidney are not responding to the ADH being produced by the pituitary
3
Q
What are the two main stimulants for ADH release?
A
hypovolemia
increased osmolarity
4
Q
What are the functions of ADH/Vasopressin?
A
reabsorb water in the DCT and CD
5
Q
How do you diagnose diabetes insipidus?
A
Pitressin (endogenous ADH) IM or IV in fluids for one hour
- if the problem is central, urine production will decrease
- if the problem is nephrogenic, the ADH will not affect the urine production
6
Q
What is the drug of choice to treat central diabetes insipidus?
A
Desmopressin / DDAVP
ADH analogue - replacement therapy
7
Q
What is the drug of choice to treat nephrogenic diabetes insipidus?
A
Thiazide diuretics
8
Q
What is the primary clinical sign associated with diabetes insipidus?
A
PU/PD
