diabetes insipidus

Question 1

osmol receptors

Answer 1

adh/vasopressin released by nuclei- stored in posterior pituitiary, released as needed. goes to kidney, adh works to cause the transport of water from renal filtrate to body.

Question 2

two types

Answer 2

pituitary/central, nephrogenic diabetes inspidius (tubules resistant to adh) like hypercalcemia nephropathy. water diuresis main sign of diabetes insipidus

Question 3

incidence

Answer 3

no age or breed incidence. young and old.

Question 4

adh release

Answer 4

two stimuli- osmotic stimulus, volume stimulus. increased in blood osmol, or decrease volume/pressure. hypovolemia.

Question 5

diagostics

Answer 5

pu/pd, normal pe, normal chemistries, hyposthenuria. water deprivation, vasopressin test, combined wd/v2test. adh trial

Question 6

differentiating central and nephrogenic

Answer 6

water deprivation- neither respond. adh- pituitary will concentrate but nephrogenic will not. water distinguishes betwene psychogenic and di.

Question 7

rx

Answer 7

DDAVP. use to conjunctiva. if dont treat is fine as long as have water, otherwise get hypertonic encephalopathy

Question 8

nephrogenic di

Answer 8

minority. have adh, but something wrong at kidney that doesnt respond to adh. treat with a diuretic. chlorothiazide. low sodium diet.

Question 9

take home messages

Answer 9

profound pu/pd. dx: water dep and adh response test. rx: DDAVP. hypertonic encephalopathy occurs with prolonged water deprivation