Diabetes Drugs/Enzymes

Question 1

Mechanism and action of Sulfonylureas?

Answer 1

Closes Katp Channels

inc pancreatic insulin secretion (sustained)

Question 2

Mechanism and action of meglitinides

Answer 2

Closes Katp Channels

inc pacnreatic insulin secretion (rapid)

Question 3

Mechanism and action of Biguanides

Answer 3

Inhibits MIto Complex 1
actiates AMP kinase

Dec heaptic gluconeogenesis
inc peripheral insulin sensitivity

Question 4

Mechanism and action of TZD

Answer 4

Activates PPARy

inc peripheral insulin sensitivity

Question 5

Mechanism and action of a-Glucosidase inhibitors

Answer 5

Blocks small bowl a glucosidase

dec intestinal carbohydrate absorption

Question 6

Mechanism and action of GLP1 analog

Answer 6

activates glp 1 receptors

inc pancreatic insulin secretion
dec glucagon secteion
delay gastric emptying
Inc satiety

Question 7

Mechanism and action of DPP-4 inhibitors

Answer 7

Inhibits DPP-4
Inc endogenous incretins

inc pancreatic insulin secretion;
dec pancreatic glucagon secretion;
delays gastric emptying
inc satiety

Question 8

Mechanism and action of amylin analogs

Answer 8

activates amylin receptors

dec pancreatic glucagon secretion;
delays gastic emptying
inc satiety

Question 9

SGLT2 Inhibitors

Answer 9

Inhibits SGLT2
Sodium glucose cotransporter 2

Glucoretic
dec renal reabsorption in the proximal tubule of the kidney