Diabetes drugs

Question 1

Which diabetes drugs cause weight gain? Which cause weight loss?

Answer 1

Gain: sulfonylureas, insulin, glitazones
Loss: GLP-1 agonists, SGLT-2 inhibitors

Question 2

AEs of metformin

Answer 2

Lactic acidosis, GI upset, metallic taste, renal impairment

Question 3

AEs of sulfonylureas

Answer 3

Hypoglycaemia, weight gain

Question 4

AEs of DPP-4 inhibitors

Answer 4

Pancreatitis

Question 5

AEs of GLP-1 agonists

Answer 5

GI upset, pancreatitis

Question 6

AEs of acarbose

Answer 6

GI upset

Question 7

AEs of glitazones

Answer 7

Fluid retention (oedema, decompensation of HF), weight gain

Question 8

AEs of SGLT-2 inhibitors

Answer 8

Glycosuria (thrush, UTI)

Question 9

Gliclazide, glimepiride - class?

Answer 9

Sulfonylureas

Question 10

Sitagliptin - class?

Answer 10

DPP-4 inhibitors

Question 11

Exenatide - class?

Answer 11

GLP-1 agonists

Question 12

Pioglitazone - class?

Answer 12

Thiazolidinediones (glitazones)

Question 13

Dapagliflozin - class?

Answer 13

SGLT-2 inhibitors

Question 14

Insulin sensitisers

Answer 14

Metformin, glitazones

Question 15

Insulin secretagogues

Answer 15

Sulfonylureas